血清sTWEAK、KLK1水平预测老年急性非ST段抬高型心肌梗死病人急诊PCI预后的研究

doi:10.3969/j.issn.1003-9198.2022.04.010

Abstract

Abstract: Objective To analyze the prediction value of serum levels of soluble tumor necrosis factor like weak inducer of apoptosis(sTWEAK) and tissue kallikrein 1(KLK1) for the prognosis of the elderly patients with acute non-ST segment elevation myocardial infarction(NSTEMI) after emergency percutaneous coronary intervention(PCI). Methods The data of 117 elderly patients with NSTEMI receiving emergency PCI in our hospital from April 2018 to December 2019 were retrospectively analyzed. The serum levels of sTWEAK, KLK1, cardiac troponin T(cTnT)and creatine kinase MB(CK-MB) at admission and 1 d after PCI were observed and compared. Aceording to the prognosis 1 year after PCI, the patients were divided into the good prognosis group and the poor prognosis group, and the serum levels of sTWEAK and KLK1 were compared between the two groups.The prediction value of serum sTWEAK and KLK1 was analyzed. Results The levels of sTWEAK, cTnT and CK-MB were significantly lower and the level of KLK1 was higher in 117 elderly patients with NSTEMI 1 day after PCI than those at admission(P<0.05). After 1 year of follow-up, there was 32 cases (27.35%)showing poor prognosis, and the level of sTWEAK in the poor prognosis group was higher and the level of KLK1 was lower than that in the good prognosis group(P<0.05).Logistic regression analysis showed that the over expression of sTWEAK (OR=1.167,95%CI: 1.095-1.243)and low expression of KLK1(OR=0.526, 95%CI: 0.402-0.688) might be risk factors for poor prognosis of emergency PCI in the elderly NSTEMI patients(P<0.05). Receiver operating characteristic curve(ROC) curve was drawn and showed that the AUC of serum sTWEAK and KLK1 or combination in predicting the prognosis of emergency PCI in the elderly NSTEMI patients was 0.814, 0.895 and 0.907 respectively. Conclusions The poor prognosis may be related to the over expression of sTWEAK and the low expression of KLK1. Early detection of sTWEAK and KLK1 levels at admission has certain predictive value for the prognosis in the elderly NSTEMI patients after the emergency PCI.

Key words: acute non ST segment elevation myocardial infarction, soluble tumor necrosis factor like weak inducer of apoptosis, tissue kallikrein-1, percutaneous coronary intervention, prognosis, prediction value

CLC Number:

R 542.22

YIN Xue-jiao, LI Hui, LIANG Rong-zhen, LIU Wen, WANG Ling-na, LIN Li. Prediction value of sTWEAK and KLK1 for the prognosis of elderly patients with acute non-ST segment elevation myocardial infarction receiving emergency percutaneous coronary intervention[J]. Practical Geriatrics, 2022, 36(4): 364-368.

References

[1] OOSTERWERFF E F J, FAGEL N D, SLAGBOOM T, et al. Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes.The ‘wait a day’ approach might be safer[J]. Neth Heart J, 2016, 24(3): 173-180.
[2] 吴彩凤,徐日新,张强,等. 微循环阻力指数评估急性前壁ST段抬高型心肌梗死患者急诊冠状动脉介入治疗预后的价值及相关影响因素[J]. 实用临床医药杂志,2019,23(16): 65-69,75.
[3] 孙筱笛,齐国先,刘闺男. 白细胞亚型对急性ST段抬高型及非ST段抬高型心肌梗死预后预测价值的研究进展[J]. 中国医刊,2017,52(4): 24-27.
[4] LIU S Y, CHEN J, LI Y F. Clinical significance of serum interleukin-8 and soluble tumor necrosis factor-like weak inducer of apoptosis levels in patients with diabetic nephropathy[J]. J Diabetes Investig, 2018, 9(5): 1182-1188.
[5] DAI S H, LI J F, FENG J B, et al. Association of serum levels of AngII, KLK1, and ACE/KLK1 polymorphisms with acute myocardial infarction induced by coronary artery stenosis[J]. J Renin Angiotensin Aldosterone Syst, 2016, 17(2): 1-10.
[6] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 非ST段抬高急性冠状动脉综合征诊断和治疗指南[J]. 中华心血管病杂志,2012,40(5): 353-367.
[7] 中国医师协会急诊医师分会,中国心胸血管麻醉学会急救与复苏分会. 中国急性心力衰竭急诊临床实践指南(2017)[J]. 中国急救医学,2017,37(12): 1063-1074.
[8] NEELAND I J, PATEL R S, ESHTEHARDI P, et al. Coronary angiographic scoring systems: An evaluation of their equivalence and validity[J]. Am Heart J, 2012, 164(4): 547-552.
[9] CARLSEN E A, HASSELL M E C J, VAN HELLEMOND I E G, et al. The stability of myocardial area at risk estimated electrocardiographically in patients with ST elevation myocardial infarction[J]. J Electrocardiol, 2014, 47(4): 540-545.
[10] ZHDAN V M, OKSAK G A, RADOMSKYI O V, et al. Epidemiology of acute myocardial infarction in Ukraine and Poltava region[J]. Wiad Lek, 2018, 71(3pt2): 751-756.
[11] BAILLEULA C, AISSAOUIB N, CAYLAC G, et al. Prognostic impact of prepercutaneous coronary intervention TIMI flow in patients with ST-segment and non-ST-segment elevation myocardial infarction: Results from the FAST-MI 2010 registry[J]. Arch Cardiovasc Dis, 2018, 111(2): 101-108.
[12] YE X D, HE Y, WANG S, et al. Heart-type fatty acid binding protein(H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis[J]. Acta Pharmacol Sin, 2018, 39(7): 1155-1163.
[13] FAN J, MA J, XIA N, et al. Clinical value of combined detection of CK-MB, MYO, cTnl and plasma NT-proBNP in diagnosis of acute myocardial infarction[J]. Clin Lab, 2017, 63(3): 427-433.
[14] RIENKS M, CARAI P, BITSCH N, et al. Sema3A promotes the resolution of cardiac inflammation after myocardial infarction[J]. Basic Res Cardiol, 2017, 112(4): 42.
[15] 段秋艳,杜秋红,宋文玲,等. 血清sTWEAK和MMP-9在急性ST段抬高型心肌梗死患者中的表达及其与预后的关系[J]. 中国医科大学学报,2019,48(9): 833-836,851.
[16] 杜秋红,徐萍. 血浆sTWEAK水平与ACS病人冠状动脉病变严重程度及预后的关系分析[J]. 中西医结合心脑血管病杂志,2019,17(4): 557-559.
[17] 刘畅,姚玉宇,马根山,等. 人血浆组织激肽释放酶结合蛋白与冠状动脉病变程度相关性研究简[J]. 南京医科大学学报(自然科学版),2016,36(10): 1208-1212.
[18] 刘彦波,韩晓雨,王贤冬,等. 组织激肽释放酶1改善大鼠心脏缺血/再灌注损伤后线粒体功能障碍[J]. 第二军医大学学报,2019,40(5): 528-534.

Prediction value of sTWEAK and KLK1 for the prognosis of elderly patients with acute non-ST segment elevation myocardial infarction receiving emergency percutaneous coronary intervention

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 10

[1]	WANG Xinping, XIE Baimei, WEI Guo, YE Xiaoli, ZHAO Yayun, TAN Xiaotian. Expression levels and clinical significance of serum S100A9 and sCD163 in elderly patients with idiopathic interstitial pneumonia [J]. Practical Geriatrics, 2024, 38(8): 802-807.
[2]	XUE Bingyan, XU Ruitong, GU Danyang, ZHU Guoqin. Correlation analysis of clinicopathologic features and prognosis in eighty-one elderly patients with pancreatic neuroendocrine tumors [J]. Practical Geriatrics, 2024, 38(7): 718-721.
[3]	CHEN Tufen, ZHANG Bo. Analysis of clinical and serological characteristics of hepatitis E in 50 elderly patients [J]. Practical Geriatrics, 2024, 38(7): 722-726.
[4]	DU Zhaona, JIANG Wenbo, MOU Junyu, YU Chengyun, XIA Wei. Risk factors and prognosis of new continuous complete left bundle branch block in elderly patients undergoing transcatheter aortic valve replacement [J]. Practical Geriatrics, 2024, 38(5): 500-437.
[5]	XIAO Wen, HU Xiu, LI Jun, SONG Bin. Relationship of neutrophil to lymphocyte ratio with prognosis of elderly patients undergoing maintenance hemodialysis [J]. Practical Geriatrics, 2024, 38(4): 372-376.
[6]	HU Yun, WANG Shuhong, XU Ji. Relationship of systemic immune-inflammation index, albumin, alpha-fetoprotein with prognosis in elderly patients with liver metastasis from gastric adenocarcinoma [J]. Practical Geriatrics, 2024, 38(4): 377-381.
[7]	PENG Zetong, ZHANG Yao, LIU Bin. Analysis of the effects of anemia on death in elderly patients with community-acquired pneumonia [J]. Practical Geriatrics, 2024, 38(3): 260-264.
[8]	CHEN Lu, YAO Junying, YU Yongyun, FAN Min. Effect of MDT immunonutritional support therapy in elderly patients undergoing craniocerebral surgery [J]. Practical Geriatrics, 2024, 38(3): 278-282.
[9]	ZHU Wugang, ZHAI Chentong, LIU Degan, XU Wenjing. Predictive value of peripheral blood neutrophil to lymphocyte ratio on prognosis for elderly patients with metastatic esophageal cancer after immunotherapy [J]. Practical Geriatrics, 2024, 38(2): 171-175.
[10]	LI Guangyao, YE Bihua, LI Xiaoliang, TANG Qin, LIU Cuihua. Relationship of ApoB/ApoA1 ratio and triglyceride glucose index with severity and prognosis of traumatic brain injury in the elderly [J]. Practical Geriatrics, 2024, 38(10): 1049-1053.
[11]	ZHANG Ming, CHEN Xi, LIU Yuehong, XIE De, WANG Zhicong, LAN Pingwen, WANG Guanglin. Relationship between red blood cell volume distribution width and prognosis of elderly patients with hip fracture [J]. Practical Geriatrics, 2024, 38(1): 22-27.
[12]	SUN Jie, ZHA Xiufang, XU Jin, ZHAO Junning, HE Wei, ZHANG Nannan. Correlation of AHNAK expression with macrophage infiltration and prognosis in patients with gastric cancer [J]. Practical Geriatrics, 2024, 38(1): 49-53.
[13]	BAI Xiao-yu, ZHANG Jun, ZHAO Peng, WEI Mei, QIU Ya-hui, FENG Xue-juan. Association of five-times sit-to-stand test with cardiac function and quality of life in elderly patients undergoing PCI [J]. Practical Geriatrics, 2023, 37(8): 777-780.
[14]	ZHANG Jian, LI Quan-rui, TIAN Geng. Value of total tetraiodothyronine combined with D-dimer and uric acid in predicting the 28-d prognosis in elderly patients with septic shock [J]. Practical Geriatrics, 2023, 37(8): 815-818.
[15]	YANG Wen-jie, LI Yan-li, ZHOU Yan-jun, LI Lan, MU Bin, WANG Jie. Clinical characteristics of stroke combined with sarcopenia and the effect of early microecological enteral nutrition intervention [J]. Practical Geriatrics, 2023, 37(8): 823-827.