Abstract: Objective To explore the association of cognitive impairment and coronary heart disease(CHD) in the elderly inpatients. Methods A total of 678 elderly patients were enrolled in this study, and were divided into CHD group (n=203) and non-CHD group (n=478). The cognitive function was assessed by Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE); Depression was evaluated by Hamilton Depression Scale (HAMD), and anxiety was evaluated by Hamilton Anxiety Scale (HAMA); Barthel index was used to assess the activities of daily living (ADL). Multivariate Logistic regression analysis was used to analyze the risk factors of CHD. Results The scores of MoCA, MMSE and Barthel index in CHD group were lower than those in non-CHD group, while the scores of HAMA and HAMD were higher than those in non-CHD group (P<0.05). Multivariate Logistic regression analysis showed that higher MoCA score was the protective factor of CHD (OR=0.962, 95% CI: 0.931-0.994) (P<0.05), and older age (OR=1.031, 95% CI: 1.004-1.058), higher HAMA score (OR=1.042, 95% CI: 1.014-1.071), longer duration of hypertension (OR=1.024, 95% CI: 1.010-1.038) and longer duration of diabetes (OR=1.036, 95% CI: 1.013-1.060) were the risk factors of CHD. Conclusions The development of CHD in the elderly inpatients may be related to old age, long course of hypertension, long course of diabetes, anxiety and cognitive impairment.

Key words: elderly inpatients, cognitive impairment, anxiety, depression, coronary heart disease