首发老年抑郁症病人睡眠纺缍波与抑郁、焦虑和认知功能的关系

doi:10.3969/j.issn.1003-9198.2024.05.017

Abstract

Abstract: Objective To analyze the relationship of sleep spindles (SS) with depression, anxiety and cognitive function in the elderly patients with first episode of depression. Methods A total of 40 patients with the first episode of geriatric depression admitted to our hospital from January 2021 to January 2022 were retrospectively selected as the elderly group, while 40 young and middle-aged patients with depression were enrolled as the young and middle-aged group, and 40 healthy elderly receiving physical examination were enrolled as the healthy group. The deletional rate and abnormal rate of SS, and the scores of Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) -17 and Montreal Cognitive Function Assessment Scale (MoCA) were compared among the three groups. The deletional rate and abnormal rate of SS were also compared between the different gender and different cognitive function subgroups. Results The SS deletion rate (57.50%) and abnormal rate (62.50%) in the elderly group were higher than those in the young and middle-aged group (32.50%, 2.50%) and the healthy group (35.00%, 2.50%) (P<0.05). HAMA score and HAMD-17 score showed no significant differences between the elderly group and the young and middle-aged group (P>0.05), but they were higher than those in the healthy group (P<0.05). The MoCA score in the elderly group was lowest, followed by the young and middle-aged group and the healthy group (P<0.05). There was no significant difference in the deletional rate of SS between the male and female elderly patients (P>0.05). The SS deletional rate in the young and middle-aged female patients was significantly lower than that in the young and middle-aged male patients and the elderly female patients (P<0.05). The deletional rate and abnormal rate of SS in the patients with cognitive dysfunction were higher than those without cognitive dysfunction in the elderly group (P<0.05). Conclusions The deletion rate and abnormal rate of SS are relatively high in the elderly patients with first episode of depression, and SS is related to cognitive function.

Key words: geriatric depression, sleep spindles, anxiety, depression, cognitive function

CLC Number:

R 479.4

WANG Jinpeng, ZHANG Shun, ZHANG Xiaojuan, WANG Liping, MA Wenyou. Relationship of sleep spindles with depression, anxiety with cognitive function in elderly patients with first episode of depression[J]. Practical Geriatrics, 2024, 38(5): 505-437.

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Relationship of sleep spindles with depression, anxiety with cognitive function in elderly patients with first episode of depression

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