FSH-FSHR信号通路在2型糖尿病性骨质疏松症中的研究进展

doi:10.3969/j.issn.1003-9198.2026.04.018

Abstract

Abstract: Type 2 diabetic osteoporosis (T2DOP) is a chronic bone metabolic disorder occurring in the context of disordered glucose metabolism, characterized by a unique“high bone density, low bone quality”phenotype and significantly increase fracture risk. Recently, the follicle-stimulating hormone (FSH) and its receptor (FSHR) signaling pathway has attracted increasing attention for its role in the pathogenesis of T2DOP. In addition to regulating gonadal function, FSH can also participate in the bidirectional regulation of glucose metabolism and bone metabolism through FSHR distributed in the pancreas, liver, adipose tissue, and bone tissue. This article systematically reviews the mechanism of action of the FSH-FSHR signaling pathway in T2DOP and explores therapeutic strategies targeting this pathway, providing novel insights for the prevention and treatment of T2DOP.

Key words: follicle-stimulating hormone, follicle-stimulating hormone receptor, signaling pathway, type 2 diabetic osteoporosis, glucose metabolism, bone metabolism

CLC Number:

HAN Xingyan, GAO Fei. Research progress of FSH-FSHR signaling pathway in type 2 diabetic osteoporosis[J]. Practical Geriatrics, 2026, 40(4): 422-426.

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Research progress of FSH-FSHR signaling pathway in type 2 diabetic osteoporosis

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