老年视力障碍药物靶点的研究进展

doi:10.3969/j.issn.1003-9198.2026.03.004

Abstract

Abstract: The global disease burden of visual impairment in the elderly is substantial, encompassing various types such as age-related cataract, age-related macular degeneration, glaucoma, diabetic retinopathy, xerophthalmia, refractive errors, and retinal vein occlusion. Current clinical treatment options face limitations including gradual drug resistance, difficulty in reversing damage, poor medication adherence, and limited therapeutic choices. Ongoing research into drug targets has become key to breaking through these therapeutic bottlenecks. This article systematically reviews the core pathological mechanisms of the aforementioned common visual impairments, summarizes recent advances in related drug target research, and finally proposes that future efforts should focus on multi-target synergistic treatment strategies, develop novel drug delivery technologies, and combine gene editing techniques to develop new therapies for visual impairment in the elderly.

Key words: visual impairment, aged, drug targets, age-related cataract, retinopathy

CLC Number:

R 77

LI Minglin, LI Minfeng, ZENG Sanlong, LIANG Qingjing, LIU Jiye, LUO Jianwen. Research advances in drug targets for visual impairment in the elderly[J]. Practical Geriatrics, 2026, 40(3): 234-240.

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Research advances in drug targets for visual impairment in the elderly

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