外周血磷酸盐水平与老年急性感染患者不良预后风险的相关性

doi:10.3969/j.issn.1003-9198.2026.03.011

Abstract

Abstract: Objective To explore the correlation between peripheral blood phosphate level and poor prognosis risk in the elderly patients with acute infections. Methods A retrospective study was conducted on 246 elderly patients with acute infections admitted to ICU of Langfang People’s Hospital from January 2019 to December 2023, with a hospitalization duration exceeding 72 hours. Based on mortality outcomes during hospitalization, the patients were divided into a survival group and a mortality group. Peripheral blood phosphate level and clinical data were collected within 24 hours of admission. Multivariate logistic regression analysis was performed to identify risk factors for poor prognosis in elderly patients with acute infections. Patients were further stratified into low-, normal-, and high-level peripheral blood phosphate groups based on admission 24-hour phosphate level. Kaplan-Meier survival curve analysis was used to evaluate the relationship between peripheral blood phosphate level and in-hospital mortality, while a multivariate Cox regression model was employed to assess the prognostic value of peripheral blood phosphate level. Results Multivariate logistic regression analysis showed that Sequential Organ Failure Assessment (SOFA) score (OR=2.343), alanine aminotransferase (OR=1.079), procalcitonin (OR=8.668), ICU stay (OR=5.390), number of antibiotics types (OR=6.131) and peripheral blood phosphate level (OR=12.314) were risk factors for poor prognosis in elderly patients with acute infections. There was a statistically significant difference in the in-hospital mortality rate among the low-level group (n=41), normal-level group (n=77) and high-level group (n=128) (P<0.01). The in-hospital mortality rate was significantly higher in the high-level group (49 cases, 38.28%) compared to the normal-level group (12 cases, 15.58%) (P<0.01), but no statistically significant difference was observed when compared with the low-level group (11 cases, 26.83%) (P>0.05). Cox regression analysis revealed that elevated peripheral blood phosphate level was independently associated with increased in-hospital mortality after adjustment for confounding factors (P<0.05). Conclusions Peripheral blood phosphate level within 24 hours after admission shows great significance for evaluation of poor prognosis risk in the elderly patients with acute infections.

Key words: acute infections, aged, peripheral blood phosphate level, risk of adverse prognosis, death in hospital

CLC Number:

R 446.11

ZHANG Liyan, FENG Xuefei, CHEN Lin, ZHAO Yonghua. Correlation between peripheral blood phosphate level and poor prognosis risk in elderly patients with acute infections[J]. Practical Geriatrics, 2026, 40(3): 278-282.

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Correlation between peripheral blood phosphate level and poor prognosis risk in elderly patients with acute infections

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