Abstract: With the acceleration of population aging, frailty as a multifactorial medical syndrome has become an important research hotspot in geriatrics and chronic disease management. The features of fraitly are loss of strength, endurance and physiological function, which can significantly increase vulnerability, functional dependence and mortality risk. The biological mechanisms driving its occurrence and progression have not been fully elucidated, which to some extent limits the development of relevant risk assessment tools and intervention strategies. In recent years, the rapid progress of multi-omics technologies and physiological/biochemical research methods has provided new research pathways for systematically elucidating the molecular basis of frailty. This article systematically reviews the latest research progress on the core molecular mechanisms driving frailty and drug targets, providing a reference for future translational studies on frailty mechanisms and precision interventions.

Key words: frailty, aged, chronic inflammation, drug target, molecular mechanism