血清甘丙肽、碱性磷酸酶、S100β水平与老年急性脑梗死伴脑微出血病人认知功能障碍的关系

doi:10.3969/j.issn.1003-9198.2025.05.014

Abstract

Abstract: Objective To investigate the relationship between serum levels of galanin, alkaline phosphatase (ALP), S100β and cognitive dysfunction in the elderly patients with acute cerebral infarction (ACI) combineed with cerebral microbleeds (CMBs). Methods A total of 110 ACI patients with CMBs (CMBs group) and 136 ACI patients without CMBs (non-CMBs group) admitted to Department of Neurology of Cangzhou People’s Hospital from June 2020 to June 2024 were enrolled in this study. The ACI patients with CMBs were divided into cognitive impairment group (47 cases) and non-cognitive impairment group (63 cases) according to the presence of cognitive dysfunction. The level of serum ALP was measured by the p-nitrophenyl phosphate assay, and the serum levels of galanin and S100β were determined by enzyme-linked immunosorbent assay.The correlation between serum levels of galanin, ALP, S100β levels and cognitive function score were evaluated by Pearson coefficients, and the influencing factors of cognitive dysfunction in ACI patients with CMBs were analyzed by multivariate logistic regression. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of galanin, ALP and S100β for cognitive dysfunction in ACI patients with CMBs. Results The levels of galanin, ALP and S100β in CMBs group were higher than those in non-CMBs group (P<0.01). The levels of galanin, ALP and S100β in cognitive impairment group were higher than those in non-cognitive impairment group (P<0.01). The serum levels of galanin, ALP, S100β were negatively correlated with the scores of Montreal Cognitive Assessment and Mini-Mental State Examination in the cognitive impairment group (P<0.01). High score of National Institutes of Health Stroke Scale, and high levels of galanin, ALP and S100β were the risk factors for cognitive dysfunction in ACI patients with CMBs. The area under the curve (AUC) of galanin, ALP and S100β in diagnosing cognitive dysfunction in ACI patients with CMBs was 0.802, 0.773 and 0.762, respectively, and the AUC of combination of the three indicators was 0.948, which was higher than that of the single indicator (all P<0.05). Conclusions Serum levels of galanin, ALP and S100β are significantly increased in ACI patients with CMBs, and are related to cognitive dysfunction. The combination of the three indicators has high value in the diagnosis of cognitive dysfunction in ACI patients with CMBs.

Key words: acute cerebral infarction, cerebral microbleed, cognitive dysfunction, galanin, alkaline phosphatase, S100β

CLC Number:

R 749.3

RAN Fang, TIAN Xuan, LIU Feng, XIE Lulu, ZHANG Jian, CHEN Linyun. Relationship between serum levels of galanin, alkaline phosphatase, S100β and cognitive dysfunction in elderly patients with acute cerebral infarction combined with cerebral microbleeds[J]. Practical Geriatrics, 2025, 39(5): 502-507.

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Relationship between serum levels of galanin, alkaline phosphatase, S100β and cognitive dysfunction in elderly patients with acute cerebral infarction combined with cerebral microbleeds

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