老年脓毒症病人的内分泌应激改变

doi:10.3969/j.issn.1003-9198.2025.04.005

Abstract

Abstract: With the accelerating pace of global aging, the incidence rate and mortality rate of sepsis among the elderly have risen significantly, posing a serious threat to public health. The elderly patients with sepsis exhibit distinct age-related characteristics in their endocrine stress responses, which not only influence the progression of sepsis but also present challenges to clinical management.This review systematically summarizes the dysfunction and underlying mechanisms of hypothalamic-pituitary-adrenal (HPA) axis, hypothalamic-pituitary-thyroid (HPT) axis, hypothalamic-pituitary-gonadal (HPG) axis and renin angiotensin-aldosterone system (RAAS) in the elderly patients with sepsis, and comprehensively analyzes the risks and benefits of hormone replacement therapy, providing a theoretical foundation for optimizing treatment strategies in the elderly patients with sepsis.

Key words: aging, sepsis, endocrine system

CLC Number:

R 631

SUN Caizhi, QIN Haidong. Endocrine stress changes in elderly patients with sepsis[J]. Practical Geriatrics, 2025, 39(4): 347-351.

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Endocrine stress changes in elderly patients with sepsis

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