实用老年医学

实用老年医学 ›› 2023, Vol. 37 ›› Issue (6): 607-611.doi: 10.3969/j.issn.1003-9198.2023.06.017

• 临床研究 • 上一篇    下一篇

老年女性2型糖尿病病人血清肌酐/胱抑素C比值与胰岛B细胞功能的相关性研究

夏运, 张光第   

  1. 226000 江苏省南通市,南通市第一人民医院老年科(夏运);
    226000 江苏省南通市,南通大学附属医院肾内科(张光第)
  • 收稿日期:2022-09-22 出版日期:2023-06-20 发布日期:2023-06-30

Correlation between serum creatinine/cystatin C ratio and islet beta-cell function in elderly women with type 2 diabetes mellitus

XIA Yun, ZHANG Guang-di   

  1. Department of Geriatrics,First People's Hospital of Nantong, Nantong 226000, China (XIA Yun);
    Department of Nephrology,Affiliated Hospital of Nantong University, Nantong 226000, China (ZHANG Guang-di)
  • Received:2022-09-22 Online:2023-06-20 Published:2023-06-30

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摘要： 目的 探讨老年女性2型糖尿病病人血清肌酐/胱抑素C比值(Cr/Cys-C)与胰岛B细胞功能的相关性。 方法 选择年龄≥65岁的老年女性T2DM病人180例,收集临床资料,行75 g口服葡萄糖耐量试验(OGTT),计算胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)、葡萄糖处置指数(DI)。根据Cr/Cys-C三分位数将病人分为3组,比较3组间胰岛B细胞功能指标。采用相关分析评估Cr/Cys-C与各胰岛功能指标的相关性。 结果 Cr/Cys-C第三分位组、第二分位组的InsAUC30、InsAUC120、HOMA-β、DI30均高于第一分位组,BMI、腰围、HbA1c水平均低于第一分位组,差异具有统计学意义(P<0.05)。Cr/Cys-C与空腹血清胰岛素(r=0.187, P=0.005)、InsAUC30(r=0.268, P<0.001)、InsAUC120(r=0.216, P=0.002)、HOMA-β(r=0.279, P<0.001)、DI30(r=0.245, P<0.001)、DI120(r=0.183, P=0.005)均呈正相关。校正了年龄、BMI、病程、HbA1c后,上述相关性仍存在(P＜0.05)。 结论 老年女性T2DM病人血清Cr/Cys-C水平与胰岛B细胞功能之间存在正相关关系。

关键词: 血清肌酐/胱抑素C比值, 2型糖尿病, B细胞功能, 老年人

Abstract: Objective To investigate the correlation between serum creatinine/cystatin C ratio (Cr/Cys-C) and pancreatic β-cell function in the elderly female patients with type 2 diabetes mellitus(T2DM). Methods A total of 180 elderly female patients with T2DM aged≥65 years were enrolled, and the general clinical data were collected. All patients underwent 75 g oral glucose tolerance test (OGTT), and insulin resistance index (HOMA-IR), insulin secretion index (HOMA-β) and glucose disposal index (DI) were calculated. All patients were divided into three groups according to the tri-sectional quantiles of Cr/Cys-C and the above indexes were compared. The relationship between Cr/Cys-C and indicator of β-cell function was analyzed. Results Compared to the lower tertile group, InsAUC30, InsAUC120, HOMA-β and DI30 were significantly higher, and the levels of body mass index (BMI), waist circumference and HbA1c were significantly lower in the middle tertile group and the upper tertile group (P<0.05). Cr/Cys-C was positively correlated with fasting serum insulin (FINS) (r=0.187, P=0.005), InsAUC30(r=0.268, P<0.001), InsAUC120(r=0.216, P=0.002), HOMA-β(r=0.279, P<0.001), DI30(r=0.245, P<0.001) and DI120(r=0.183, P=0.005). After adjusting age, BMI, disease duration and HbA1c, these correlations were still present (P<0.05). Conclusions There is a positive correlation between serum Cr/Cys-C and pancreatic β-cell function in the elderly female patients with T2DM.

Key words: serum creatinine/cystatin C ratio, type 2 diabetes mellitus, beta cell function, aged

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