基于Solumbra技术的取栓术治疗老年脑梗死病人的疗效及其神经损伤标志物水平变化

doi:10.3969/j.issn.1003-9198.2023.06.016

摘要/Abstract

摘要： 目的探究Solumbra取栓对老年脑梗死的疗效及其对血清神经损伤标志物的影响。方法 2019年1月至2021年1月我院收治的220例脑梗死病人随机分为观察组和对照组,每组110例。观察组采用Solumbra 技术取栓,对照组采用常规技术取栓,比较2组临床疗效、不良事件发生情况、神经功能缺损评分(NIHSS),以及血清脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)、神经生长因子(NGF)水平及改良Rankin量表评分(mRS)。结果观察组取栓次数、取栓时间显著短于对照组,一次再通率(53.63%)显著高于对照组(36.36%),脑梗死溶栓(TICI)分级显著优于对照组(P＜0.05)。观察组二次栓塞发生率(6.36%)显著低于对照组(17.27%)(P＜0.05)。观察组术后72 h、1周、30 d NIHSS评分均显著低于对照组(P＜0.01)。术后30 d,观察组BDNF、NGF水平显著高于对照组,NSE水平低于对照组,差异有统计学意义(P＜0.01)。术后90 d,观察组预后良好率和mRS评分显著优于对照组(P＜0.05)。结论 Solumbra取栓术能有效提高老年脑梗死的临床疗效,改善神经功能和神经损伤标志物水平。

关键词: 机械取栓, Solumbra, 老年人, 脑梗死, 二次栓塞, 神经损伤标志物

Abstract: Objective To analyze the clinical efficacy of Solumbra technology in the treatment of the elderly patients with cerebral infarction and the effects on the serum nerve injury markers. Methods A total of 220 patients with cerebral infarction admitted to our hospital from January 2019 to January 2021 were randomly divided into the observation group and the control group, with 110 cases in each group. The observation group was treated with Solumbra technique, and the control group was treated with conventional stent thrombectomy. The clinical effect, adverse events, the scores of National Institute of Health Stroke Scale(NIHSS) and modified Rankin Scale (mRS), the levels of serum brain-derived neurotrophic factor (BDNF), neuron specific enolization (NSE) and nerve growth factor (NGF) were compared between the two groups. Results The number of thrombectomy and thrombectomy time were significantly lower, and the first-pass revascularization rate was significantly higher in the observation group than those in the control group (P<0.05). The thrombolysis in cerebral infarction (TICI) grade of the observation group was significantly better (P<0.05), and the incidence rate of secondary embolism was significantly lower in the observation group than those in the control group. The NIHSS score of the observation group was significantly lower than that of the control group 72 hours, 1 week and 30 days after operation (P<0.01). Thirty days after operation, the levels of BDNF and NGF were significantly higher, and the level of NSE was significantly lower in the observation group than those in the control group (P<0.01). Ninety days after operation, the good prognosis rates and mRS score of the observation group were significantly higher than those of the control group(P<0.05). Conclusions Solumbra thrombectomy can effectively improve the clinical efficacy and improve the neurological function and nerve injury markers.

Key words: stent thrombectomy, Solumbra, aged, cerebral infarction, secondary embolization, nerve injury markers

中图分类号:

R 743.33

柏建兵, 王阳, 李子标, 向文杰. 基于Solumbra技术的取栓术治疗老年脑梗死病人的疗效及其神经损伤标志物水平变化[J]. 实用老年医学, 2023, 37(6): 603-606.

BAI Jian-bing, WANG Yang, LI Zi-biao, XIANG Wen-jie. Effect of Solumbra technology in the treatment of elderly patients with cerebral infarction and the change of nerve injury markers[J]. Practical Geriatrics, 2023, 37(6): 603-606.

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