Practical Geriatrics ›› 2025, Vol. 39 ›› Issue (5): 534-538.doi: 10.3969/j.issn.1003-9198.2025.05.020

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Research advance of frailty assessment in patients with multiple myeloma

GAO Jingyu, WANG Ting, TAN Simin   

  1. Department of Hematology, Peking University People’s Hospital, Beijing 100044, China(GAO Jingyu, WANG Ting); Department of Hematology, the Third Xiangya Hospital, Central South University, Changsha 410000, China(TAN Simin)
  • Received:2024-08-22 Online:2025-05-20 Published:2025-05-20
  • Contact: TAN Simin, Email: simintan@csu.edu.cn

Abstract: Frailty is a common geriatric syndrome that significantly affects the efficacy and safety of treatment in the patients with multiple myeloma. Screening for frailty is particularly important for the selection of treatment methods and the prediction of adverse event risks for multiple myeloma. This article summarizes the conceptual model and potential biomarkers of frailty, and frailty assessment tool for the patients with multiple myeloma, and analyzes the advantages, disadvantages and clinical application value of various assessment methods for multiple myeloma. It points out that frailty can be used as a predictor of risk in the patients with multiple myeloma. However, future studies still need to further refine the evaluation indicators of frailty in the patients with multiple myeloma, and to improve its application value for multiple myeloma.

Key words: multiple myeloma, frailty, biomarker, assessment tool, predictive indicator

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