Practical Geriatrics ›› 2025, Vol. 39 ›› Issue (2): 121-126.doi: 10.3969/j.issn.1003-9198.2025.02.004

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Advance in the diagnosis and treatment of Alzheimer's disease

XIN Mengfan, FENG Meijiang   

  1. Department of Geriatrics, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210003, China
  • Received:2024-10-25 Online:2025-02-20 Published:2025-03-03
  • Contact: FENG Meijiang, Email: mjfeng416@163.com

Abstract: Alzheimer's disease(AD) is a neurodegenerative disease that occurs in late adulthood and early old age, characterized by an insidious onset and a progressive course, with a poor prognosis. Its central syndrome is acquired cognitive impairment, affecting various cognitive domains including memory, learning, orientation, understanding, judgment, calculation, language and visuospatial skills. These impairments can significantly impact daily living abilities and social occupational functions, ultimately progressing to complete dementia. This article reviews the evolution of diagnostic criteria for AD, relevant diagnostic biomarkers, and advances in treatment, aiming to enhance the accuracy of early diagnosis and the precision of treatment for AD.    

Key words: Alzheimer's disease, diagnostic criteria, biomarker, early diagnosis, modifying treatment

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