阿尔茨海默病病人血液、尿液的代谢组学研究

doi:10.3969/j.issn.1003-9198.2021.07.008

Abstract

Abstract: Objective To explore the changes of metabolites in serum and urine in the patients with Alzheimer's disease (AD), so as to provide basis for early diagnosis of AD. Methods The content of 17 kinds of amino acids in blood and urine of the elderly AD patients (AD group) and the healthy elderly (control group) were detected by automatic amino acid analyzer. All urine samples were detected by UPLC-QETOF-MS, and biomarkers were screened by multivariate statistical analysis. Results The levels of the amino acids as Thr, Ser, Val and Lys in urine and the levels of Thr, Cys,Met and Leu in blood were significantly different between AD group and control group (P<0.05). There were 15 metabolites in urine of AD group were detected, which were not detected in control group. Conclusions Compared with the healthy elderly, there are significant differences in the contents of metabolites in serum and urine of the elderly with AD. Some metabolites may be used as potential metabolic markers for clinical diagnosis and treatment of AD.

Key words: Alzheimer's disease, metabonomics, amino acids, biomarkers

CLC Number:

R 742.5

CUI Yu, SUN Hong, WANG Xiao-kun, ZHANG Yan. Metabonomics study of blood and urine in patients with Alzheimer's disease[J]. Practical Geriatrics, 2021, 35(7): 692-695.

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Metabonomics study of blood and urine in patients with Alzheimer's disease

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