Abstract: Objective To investigate the predictive value of serum laminin (LN) level for the prognosis of acute heart failure (AHF) in the elderly. Methods A total of 238 elderly patients with AHF admitted to Nantong First People’s Hospital from July 2019 to November 2020 were enrolled in this study. The baseline data and the occurrence of major adverse cardiovascular event (MACE) were recorded and collected. Based on the occurrence of MACE, the patients were divided into event group and non-event group.The differences in the baseline data between the two groups were analyzed. Multiple logistic regression analysis was used to investigate the influencing factors of MACE. Receiver operating characteristic (ROC) curve analysis was used to investigate the predictive value of LN for prognosis. Results There were 53 patients presenting with MACE. The levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), LN, hyaluronic acid, aminoterminal propeptide of type Ⅲ procollagen, creatinine, C-reactive protein (CRP), left ventricular end-diastolic diameter, left ventricular end-systolic diameter, systolic blood pressure, glycocholic acid and left ventricular ejection fraction (LVEF), and the proportion of acute decompensated heart failure showed significant differences between event group and non-event group (P<0.05).The levels of LN and LVEF were the independent influencing factors of MACE.The area under the ROC curve of LN in predicting in-hospital MACE in the elderly patients with AHF was 0.742,with cut-off point of 92.5 ng/mL, sensitivity of 59.6%, specificity of 77.1%(P<0.001). Conclusions LN may serve as a potential biomarker to predict the in-hospital prognosis in the elderly patients with AHF.

Key words: acute heart failure, N-terminal pro-brain natriuretic peptide, laminin, in-hospital prognosis