Practical Geriatrics ›› 2025, Vol. 39 ›› Issue (4): 387-390.doi: 10.3969/j.issn.1003-9198.2025.04.013

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Relationship between pan-immune-inflammation index and the severity of diabetic retinopathy with macular edema in elderly patients

AN Fangjie, LIU Ying, ZHAO He   

  1. Department of Ophthalmology, Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing 100144, China
  • Received:2024-07-02 Online:2025-04-20 Published:2025-04-22
  • Contact: LIU Ying,Email:1069308412@qq.com

Abstract: Objective To explore the relationship between pan-immune-inflammation index (PIV) and the severity of macular edema in the elderly with diabetic retinopathy. Methods A total of 98 elderly patients with diabetic retinopathy admitted to Beijing Rehabilitation Hospital Affiliated to Capital Medical University from January 2021 to January 2024 were enrolled in this study. The patients without macular oedema were enrolled in the control group (n=20), and the patients with macular edema were enrolled in the observation group (n=78). According to the severity of macular edema, the patients in the observation group were divided into mild group (n=23), moderate group (n=39) and severe group (n=16). The baseline data were compared among the groups. Logistic regression analysis was used to analyze the influencing factors of macular edema in the elderly patients with diabetic retinopathy. Results There were significant differences in the duration of diabetes, the levels of hemoglobin A1c (HbA1c), interleukin-6 (IL-6) and PIV between the observation group and the control group (P<0.01). Logistic regression analysis showed that the duration of diabetes, the levels of HbA1c, IL-6 and PIV were independent influencing factors for macular edema in the elderly patients with diabetic retinopathy (P<0.05). There were significant differences in the levels of PIV, HbA1c and IL-6 among mild group, moderate group and severe group (P<0.05). PIV was positively correlated with the levels of HbA1c and IL-6 (r=0.611, P<0.01; r=0.653, P<0.01). Conclusions PIV is closely related to the severity of macular edema in the elderly patients with diabetic retinopathy, which can be used as an important indicator to evaluate the severity of macular edema in the elderly patients with diabetic retinopathy, and to provide reference for clinical diagnosis and treatment.

Key words: diabetic retinopathy, pan-immune-inflammation index, macular edema, aged

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