CONUT评分对Ⅱ/Ⅲ期老年结肠癌病人术后辅助化疗耐受性及预后的预测研究

doi:10.3969/j.issn.1003-9198.2025.03.006

Abstract

Abstract: Objective To explore the predictive value of CONUT scoring system in the elderly patients with stage Ⅱ/Ⅲ colon cancer who received postoperative adjuvant chemotherapy. Methods The data of 86 patients who underwent postoperative adjuvant chemotherapy for colon cancer in Nanjing First Hospital from January 2018 to January 2022 were retrospectively analyzed and divided into low CONUT group and high CONUT group according to the preoperative CONUT score. The clinical characteristics, chemotherapy compliance and complications were compared between the two groups, and the survival prognosis was further analyzed. Results The incidence rate of grade Ⅲ/Ⅳ neutrophil deficiency was significantly higher in the high CONUT group than that in the low CONUT group (P<0.05), and the days of chemotherapy delay was significantly longer than that in the low CONUT group (P<0.05). Survival analysis showed that the patients in the high CONUT group had significantly worse disease free survival (DFS) and overall survival (OS) than those in the low CONUT group (P<0.05). Conclusions The CONUT score can be used to assist in evaluating the response to postoperative adjuvant chemotherapy and clinical prognosis in the elderly patients with colon cancer.

Key words: controlling nutritional status score, aged, colon cancer, adjuvant chemotherapy, prognosis

CLC Number:

R 735.35

WEI Xiaowei, ZHANG Linzhu, ZHANG Juan, ZHOU Jin. Predictive effect of CONUT score on tolerance of postoperative adjuvant chemotherapy and prognosis in elderly patients with stage Ⅱ/Ⅲ colon cancer[J]. Practical Geriatrics, 2025, 39(3): 241-244.

References

[1] SUNG H, FERLAY J, SIEGELR L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
[2] VOUTSADAKISI A. Presentation, molecular characteristics, treatment, and outcomes of colorectal cancer in patients older than 80 years old[J]. Medicina, 2023, 59(9): 1574.
[3] JIANG H, WANG Z. Prognostic role of the controlling nutritional status(CONUT) score in patients with biliary tract cancer: a meta-analysis[J]. Ann Med, 2023, 55(2): 2261461.
[4] 孙倩倩, 陶洁. CONUT评分在评估弥漫大B细胞淋巴瘤患者预后中的作用[J]. 重庆医学, 2023, 52(S1): 170-172.
[5] ZHANG J, LI M, ZHANG L, et al. Prognostic value of controlling nutritional status on clinical and survival outcomes in cancer patients treated with immunotherapy[J]. Sci Rep, 2023, 13: 17715.
[6] IGNACIO DE UlÍBARRI J, GONZÁLEZ-MADROO A,DE VILLAR N G,et al.CONUT: a tool for controlling nutritional status. First validation in a hospital population[J]. Nutr Hosp, 2005, 20(1):38-45.
[7] BENSONA B, VENOOKA P, ADAM M, et al. Colon cancer, version 3.2024, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw, 2024, 22(2 D): e240029.
[8] 吴小材, 尹路. 局部进展期结肠癌综合治疗现状[J]. 结直肠肛门外科, 2023, 29(4): 337-340.
[9] NITSCHE U, STÖSS C, FRIESS H. Effect of adjuvant chemotherapy on elderly colorectal cancer patients: lack of evidence[J]. Gastrointest Tumors, 2017, 4(1/2): 11-19.
[10] GALLOIS C, SHI Q, PEDERSONL D, et al. Oxaliplatin-based adjuvant chemotherapy in older patients with stage Ⅲ colon cancer: an ACCENT/IDEA pooled analysis of 12 trials[J]. J Clin Oncol, 2024, 42(19): 2295-2305.
[11] 马丽娜, 吉彤, 李海龙, 等. 老年人营养不良多学科决策模式中国专家共识(2023)[J]. 中国临床保健杂志, 2023, 26(4): 433-445.
[12] YAMAURA T, ARIZUMI F, MARUO K, et al. The impact of Controlling Nutritional Status(CONUT) score on functional prognosis in hospitalized elderly patients with acute osteoporotic vertebral fractures[J]. BMC Geriatr, 2022, 22(1): 1002.
[13] 徐晓飞, 李阳, 陈凌云, 等. 预后营养指数和控制营养状态在乳腺癌中的研究进展[J]. 肿瘤防治研究, 2022,49(9): 961-964.
[14] 张耀森, 卢国杰, 钟惠铃, 等. 术前控制营养状态评分对非小细胞肺癌患者根治术后复发转移的预测价值分析[J]. 肿瘤综合治疗电子杂志, 2022, 8(4): 71-75.
[15] YAMAMOTO M, SAITO H, UEJIMA C, et al. Prognostic value of combined tumor marker and controlling nutritional status(CONUT) score in colorectal cancer patients[J]. Yonago Acta Med, 2019, 62(1): 124-130.

Predictive effect of CONUT score on tolerance of postoperative adjuvant chemotherapy and prognosis in elderly patients with stage Ⅱ/Ⅲ colon cancer

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 0

[1]	LI Xiang, LI Xuan, TIAN Yingxuan. Epidemiological characteristics of chronic respiratory diseases in the elderly [J]. Practical Geriatrics, 2025, 39(3): 217-222.
[2]	WU Ziwen, ZHANG Li. Epidemiological characteristics of chronic neurological diseases in the elderly [J]. Practical Geriatrics, 2025, 39(3): 223-227.
[3]	ZHANG Yiru, WANG Yao, WANG Bin. Epidemiological characteristics and prevention strategies of chronic kidney disease in the elderly in China [J]. Practical Geriatrics, 2025, 39(3): 228-231.
[4]	ZHOU Kaiwen, LAI Piao, WANG Minhong, CHENG Ruoxi, YANG Lijun, WENG Xiaofen, ZHU Gengchao, ZHANG Li. Correlation between serum creatinine-to-cystatin C ratio and physical performance in elderly people [J]. Practical Geriatrics, 2025, 39(3): 232-235.
[5]	ZHANG Yue, LIU Wen, ZHOU Zhiqiang. Correlation between preoperative peripheral inflammation phenotypes and postoperative delirium in elderly patients: a latent class analysis based on inflammatory markers [J]. Practical Geriatrics, 2025, 39(3): 236-240.
[6]	LIU Niu, WU Yiyun, ZHOU Zhengguo, DONG Weilu. Comparative study on the diagnosing value of ACR-TIRADS and C-TIRADS for thyroid nodules in elderly [J]. Practical Geriatrics, 2025, 39(3): 245-248.
[7]	WANG Hong, WANG Qing, ZHANG Jianwei, MENG Lijun, TIAN Ting, DENG Hui. Effect of multicomponent exercise in elderly patients with stable chronic obstructive pulmonary disease and frailty [J]. Practical Geriatrics, 2025, 39(3): 249-253.
[8]	JIANG Rui, GAO Yue, DU Wei, YANG Hao, DONG Qingshan, LI Xianjin, LI Shijie, HAN Bing. Effects of discontinuing anticoagulation therapy on long-term prognosis in elderly patients with non-valvular atrial fibrillation [J]. Practical Geriatrics, 2025, 39(3): 254-257.
[9]	LI Guoyuan, LIU Changying, HAO Xiaodan, CHENG Hui, YUAN Shuxuan, CHEN Jieyu, WANG Zhang. Correlation between early dynamic changes of immune cells and pulmonary infection in elderly patients with acute respiratory distress syndrome [J]. Practical Geriatrics, 2025, 39(3): 263-267.
[10]	CUI Yin, ZHANG Fujun, MA Zhengliang, GU Xiaoping. Development trajectory of cognitive function in elderly patients undergoing robot-assisted laparoscopic urological surgery [J]. Practical Geriatrics, 2025, 39(3): 282-285.
[11]	GUO Jing, ZHANG Lixia, ZHENG Juan, XU Hua, CHAI Shujuan. Effects of moderate intensity aerobic exercise on elderly patients with mild to moderate post-stroke depression [J]. Practical Geriatrics, 2025, 39(3): 286-289.
[12]	WANG Xiaoqin, FANG Zhenkun, WU Chenkai, ZHANG Yu. Effect of dietary nutrition literacy on nutritional risk of elderly people in the community [J]. Practical Geriatrics, 2025, 39(3): 290-293.
[13]	LIU Xuande, ZHOU Shigong, XU Zhuqin, SHAN Shoujie. Levels and diagnostic value of serum semaphorin 7A in elderly patients with acute coronary syndrome [J]. Practical Geriatrics, 2025, 39(3): 294-297.
[14]	ZHAO Siyi, LIU Mengya, CHANG Yuqing, GUO Wenjing, ZHANG Meng, ZHANG Li. Cut-off value of grip strength and the relationship with intrinsic capability in Chinese elderly [J]. Practical Geriatrics, 2025, 39(3): 298-302.
[15]	LI Fenhong, WEI Yanan, WU Mengli, SHEN Xiaohui, TANG Leilei. Enhanced recovery after surgery(ERAS) principles in nutritional management for elderly patients with head and neck cancer perioperatively [J]. Practical Geriatrics, 2025, 39(2): 134-138.