转录因子激活蛋白-2a在老年肺腺癌病人中的表达情况及与临床病理参数的相关性

doi:10.3969/j.issn.1003-9198.2021.10.010

Abstract

Abstract: Objective To investigate the expression of transcription factor activator protein-2a (TFAP-2a) in the elderly patients with lung adenocarcinoma and its relationship with clinicopathological parameters. Methods The difference of TFAP-2a expression between lung adenocarcinoma and normal lung tissue and its effect on the prognosis of lung adenocarcinoma were analyzed by bioinformatics data. A total of 64 cases of elderly lung adenocarcinoma tissue and 25 cases of elderly normal lung tissue were collected from August 2015 to March 2020, and the expression of TFAP-2a was detected by immunohistochemical staining, and the correlation between TFAP-2a expression and clinicopathological parameters was analyzed. Results The GEPIA database analysis results showed that the expression level of TFAP-2a in lung adenocarcinoma tissue was significantly higher than that in normal lung tissue (P<0.05), but there were no significant differences among lung adenocarcinoma tissues with different TNM staging (P>0.05). KMplot database analysis results showed that the progression-free survival and overall survival of the patients with lung adenocarcinoma with low expression of TFAP-2a were better than those with high expression of TFAP-2a (all P<0.05). The immunohistochemical staining results showed that the proportion of high expression of TFAP-2a in the elderly lung adenocarcinoma tissue was significant higher than that in the elderly normal lung tissue (P<0.01), and the proportion of high expression of TFAP-2a in the elderly patients with lung adenocarcinoma who had lymph node metastasis and moderate-low differentiation was higher (P<0.05). Conclusions TFAP-2a is highly expressed in the elderly patients with lung adenocarcinoma. The lung adenocarcinoma with over expression of TFAP-2a is poorer in differentiation and more prone to lymph node metastasis.

Key words: transcription factor activator protein-2a, lung adenocarcinoma, prognosis, bioinformatics

CLC Number:

R 734.2

FANG Le-ping, FAN Wei-fei, DONG Zhen. Expression of transcription factor activator protein-2a in elderly patients with lung adenocarcinoma and its relationship with clinicopathological parameters[J]. Practical Geriatrics, 2021, 35(10): 1036-1039.

References

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Expression of transcription factor activator protein-2a in elderly patients with lung adenocarcinoma and its relationship with clinicopathological parameters

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