血清PGC-1α、Omentin-1对老年股骨粗隆间骨折病人术后髋关节功能不良的预测价值

doi:10.3969/j.issn.1003-9198.2025.05.012

Abstract

Abstract: Objective To analyze the predictive value of serum levels of peroxisome proliferator activated receptor gamma coactivator-1α (PGC-1α) and Omentin-1 for postoperative hip joint dysfunction in the elderly patients with intertrochanteric fractures of the femur (IFF). Methods A total of 114 elderly patients with IFF who underwent surgical treatment in the Orthopedics Department of Shijiazhuang Third Hospital from June 2017 to June 2023 were enrolled in this study. Based on an 8-month follow-up after surgery, the patients were divided into poor prognosis group (30 cases) and good prognosis group (84 cases). The serum levels of PGC-1α and Omentin-1 were measured by enzyme linked immunosorbent assay. Multiple logistic regression (step forward method) was applied to analyze the influencing factors of postoperative hip joint dysfunction in the elderly patients with IFF. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of PGC-1α and Omentin-1 for postoperative hip joint dysfunction in the elderly patients with IFF, and the area under the curve (AUC) was calculated. Results The serum levels of PGC-1α and Omentin-1 in poor prognosis group were significantly lower than those in good prognosis group (P<0.01). There were significant differences in age, preoperative AO classification between the two groups (P<0.05). Multivariable logistic regression analysis showed that preoperative AO classification,the levels of PGC-1α and Omentin-1 were independent influencing factors for postoperative hip joint dysfunction in the elderly patients with IFF. The AUC of serum PGC-1α combined with Omentin-1 in predicting postoperative hip joint dysfunction was 0.942 (95%CI: 0.899-0.984), which was superior to those of PGC-1α alone(AUC=0.825, Z=2.468, P=0.014) and Omentin-1 alone (AUC=0.819, Z=2.500, P=0.012). Conclusions Serum levels of PGC-1α and Omentin-1 are down-regulated in the elderly IFF patients with postoperative hip joint dysfunction. The combination of the two indicators can improve the predictive value for hip joint dysfunction and provide clinical reference for prognosis.

Key words: intertrochanteric fracture of the femur, hip joint function, peroxisome proliferator-activated receptor gamma coactivator-1, Omentin-1

CLC Number:

R 683.42

LIN Pengchao, LI Jing, BAI Jiayue, GAO Weijing, GE Ruihong, LU Huiqing, WANG Wenjuan, HAO Kangning, WANG Jiangyong, ZHOU Xiaobin, FENG Jianshu. Predictive value of serum PGC-1α and Omentin-1 for postoperative hip joint dysfunction in elderly patients with intertrochanteric fractures of the femur[J]. Practical Geriatrics, 2025, 39(5): 492-496.

References

[1] KONG M, TANG Y, TONG F, et al. The analgesic efficacy of pericapsular nerve group block in patients with intertrochanteric femur fracture: a randomized controlled trial[J]. PLoS One, 2022,17(10):e0275793.
[2] POLAT G, BAYRAM S, GÖKÇEOĠLU Y S, et al. The effect of bone morphology on fracture type and treatment result in patients with intertrochanteric femur fracture aged over 65 year[J]. Ulus Travma Acil Cerrahi Derg, 2022,28(12):1731-1738.
[3] SING C W, LIN T C, BARTHOLOMEW S, et al. Global epidemiology of hip fractures: secular trends in incidence rate, post-fracture treatment, and all-cause mortality[J]. J Bone Miner Res, 2023,38(8):1064-1075.
[4] ABU SHELBAYEH O, ARROUM T, MORRIS S, et al. PGC-1α is a master regulator of mitochondrial lifecycle and ROS stress response[J]. Antioxidants: Basel, 2023,12(5):1075.
[5] LI Y, FU G, GONG Y, et al. BMP-2 promotes osteogenic differentiation of mesenchymal stem cells by enhancing mitochondrial activity[J]. J Musculoskelet Neuronal Interact, 2022,22(1):123-131.
[6] ZHAO A, XIAO H, ZHU Y, et al. Omentin-1: a newly discovered warrior against metabolic related diseases[J]. Expert Opin Ther Targets, 2022,26(3):275-289.
[7] HUANG X, CHEN C, CHEN Y, et al. Omentin-1 alleviate interleukin-1β(IL-1β)-induced nucleus pulposus cells senescence[J]. Bioengineered, 2022,13(5):13849-13859.
[8] 蔡振存,王鑫淼,初金泽,等. 老年人A2型股骨粗隆间骨折PFNA和DHS固定疗效比较[J]. 中国老年学杂志, 2016,36(17):4279-4281.
[9] YU Y, WANG Y, HOU X, et al. Recent advances in the identification of related factors and preventive strategies of hip fracture[J]. Front Public Health, 2023,11:1006527.
[10] ZHANG C, CHEN Z, WANG M, et al. Comparison of clinical outcomes with proximal femoral nail anti-rotation versus dynamic hip screw for unstable intertrochanteric femoral fractures: a meta-analysis[J]. Medicine: Baltimore, 2023,102(6):e32920.
[11] CHEN H, FAN W, HE H, et al. PGC-1: a key regulator in bone homeostasis[J]. J Bone Miner Metab, 2022,40(1):1-8.
[12] KIM D Y, KO S H. Common regulators of lipid metabolism and bone marrow adiposity in postmenopausal women[J]. Pharmaceuticals: Basel, 2023,16(2):322.
[13] 廖宏伟,李学栋,马金锋. 血清CTRP3及PGC-1α表达与创伤性骨折愈合的相关性分析[J]. 中国骨伤, 2022,35(11):1059-1064.
[14] TSENG C, HAN Y, LV Z, et al. Glucose-stimulated PGC-1α couples with CBP and Runx2 to mediate intervertebral disc degeneration through transactivation of ADAMTS4/5 in diet-induced obesity mice[J]. Bone, 2023,167:116617.
[15] YU M, WANG D, CHEN X, et al. BMSCs-derived mitochondria improve osteoarthritis by ameliorating mitochondrial dysfunction and promoting mitochondrial biogenesis in chondrocytes[J]. Stem Cell Rev Rep, 2022,18(8):3092-3111.
[16] SENA C M. Omentin: a key player in glucose homeostasis, atheroprotection, and anti-inflammatory potential for cardiovascular health in obesity and diabetes[J]. Biomedicines, 2024,12(2):284.
[17] KARAMPELA I, VALLIANOU NG, TSILINGIRIS D, et al. Diagnostic and prognostic value of serum Omentin-1 in sepsis: a prospective study in critically ill patients[J]. Medicina: Kaunas, 2023,59(5):833.
[18] KO C Y, LIN Y Y, ACHUDHAN D, et al. Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization[J]. Int J Biol Sci, 2023,19(16):5275-5289.
[19] CABRAL V L F, WANG F, PENG X, et al. Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells[J]. Arch Gerontol Geriatr, 2022,102:104748.
[20] TANG C, LIANG D, QIU Y, et al. Omentin-1 induces osteoblast viability and differentiation via the TGF-β/Smad signaling pathway in osteoporosis[J]. Mol Med Rep, 2022,25(4):132.

Predictive value of serum PGC-1α and Omentin-1 for postoperative hip joint dysfunction in elderly patients with intertrochanteric fractures of the femur

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