老年肺部感染病人致病菌耐药情况及耐药程度对血清IL-6、IL-10、CRP水平的影响

doi:10.3969/j.issn.1003-9198.2025.01.019

Abstract

Abstract: Objective To investigate the drug resistance of pathogenic bacteria in the elderly patients with pulmonary infection and the effects of drug resistance degree on the serum levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and C-reactive protein (CRP). Methods A total of 214 elderly patients with pulmonary infection hospitalized in Yuncheng Central Hospital from May 2020 to May 2023 were selected to analyze the drug resistance of pathogenic bacteria, and the effects of species and drug resistance of pathogenic bacteria on the levels of serum IL-6, IL-10 and CRP were investigated. The correlation of serum IL-6, IL-10, CRP with the drug resistance degree of different pathogens was analyzed by Spearman correlation analysis. Results A total of 265 strains of pathogenic bacteria were detected in the sputum samples of 214 elderly patients with pulmonary infection. The proportion of Gram-negative bacteria and Gram-positive bacteria was 76.26% (202/265) and 23.77% (63/265), respectively. Of all cases, 47 cases showed general drug resistance (21.96%), and 105 cases showed multi-drug resistance (49.07%) and 62 cases showed extensive drug resistance (28.97%). There was no significant difference in drug resistance between the patients infected with Gram-negative bacteria and those infected with Gram-positive bacteria (P>0.05), but the serum levels of IL-6, IL-10 and CRP in the patients infected with Gram-negative bacteria were higher than those in the patients infected with Gram-positive bacteria (P <0.05). The levels of IL-6, IL-10 and CRP in the patients presenting with general drug resistance were lower than those in the patients presenting with multi-drug resistance, and the levels of IL-6, IL-10 and CRP in the patients presenting with multi-drug resistance were lower than those in the patients presenting with extensive drug resistance (P <0.05). Spearman correlation analysis showed that the levels of serum IL-6, IL-10 and CRP were positively correlated with the degree of drug resistance (P<0.05). Conclusions Gram-negative bacteria are the main pathogens in the elderly patients with pulmonary infection, and the proportion of multi-drug resistance is relatively high. The levels of serum IL-6, IL-10 and CRP are correlated with the degree of drug resistance of pathogenic bacteria. The degree of drug resistance of the pathogenic bacteria can be preliminarily estimated according to the levels of serum inflammatory factors, which can be used to guide the rational use of antibiotics in clinic.

Key words: aged, lung infection, pathogenic bacteria, drug resistance, interleukin-10, C-reactive protein, interleukin-6

CLC Number:

R 563.1

LI Ting, PEI Junfang, SUN Shanshan. Drug resistance of pathogenic bacteria and effects of drug resistance degree on serum levels of IL-6, IL-10 and CRP in elderly patients with pulmonary infection[J]. Practical Geriatrics, 2025, 39(1): 83-87.

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Drug resistance of pathogenic bacteria and effects of drug resistance degree on serum levels of IL-6, IL-10 and CRP in elderly patients with pulmonary infection

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