实用老年医学 ›› 2024, Vol. 38 ›› Issue (3): 304-307.doi: 10.3969/j.issn.1003-9198.2024.03.022
廖星月, 杨茜岚, 何慧薇
收稿日期:
2023-04-20
出版日期:
2024-03-20
发布日期:
2024-03-26
通讯作者:
何慧薇,Email:13851821696@163.com
基金资助:
Received:
2023-04-20
Online:
2024-03-20
Published:
2024-03-26
摘要: 随着人口老龄化程度不断加深,肌少症已经成为影响老年人群身体健康和生活质量的重要公共卫生问题。Hcy水平升高可以导致细胞发生氧化应激、促进蛋白质聚集和功能紊乱、刺激细胞凋亡、诱发炎症等,在一定程度上影响肌少症的发生发展。关于Hcy水平与肌少症发病机制之间的研究结果尚存争议,本文就Hcy与肌少症之间的关系予以综述。
中图分类号:
廖星月, 杨茜岚, 何慧薇. 血同型半胱氨酸与肌少症关系的研究进展[J]. 实用老年医学, 2024, 38(3): 304-307.
[1] CRUZ-JENTOFT A J, BAHAT G, BAUER J, et al. Sarcopenia: revised European consensus on definition and diagnosis [J]. Age Ageing, 2019, 48(1): 16-31. [2] CRUZ-JENTOFT A J, BAEYENS J P, BAUER J M, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People [J]. Age Ageing, 2010, 39(4): 412-423. [3] YANG L, YAO X, SHEN J, et al. Comparison of revised EWGSOP criteria and four other diagnostic criteria of sarcopenia in Chinese community-dwelling elderly residents [J]. Exp Gerontol, 2020, 130: 110798. [4] CHEN L K, WOO J, ASSANTACHAI P, et al. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment [J]. J Am Med Dir Assoc, 2020, 21(3): 300-307 . [5] CHEN Z, LI W Y, HO M, et al. The prevalence of sarcopenia in Chinese older adults: meta-analysis and meta-regression [J]. Nutrients, 2021, 13(5) :1441. [6] LANDI F, CALVANI R, TOSATO M, et al. Protein intake and muscle health in old age: from biological plausibility to clinical evidence [J]. Nutrients, 2016, 8(5) :295. [7] VIDONI M L, PETTEE GABRIEL K, LUO S T, et al. Relationship between homocysteine and muscle strength decline: The Baltimore Longitudinal Study of Aging [J]. J Gerontol A Biol Sci Med Sci, 2018, 73(4): 546-551. [8] BLOM H J, SMULDERS Y. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects [J]. J Inherit Metab Dis, 2011, 34(1): 75-81. [9] KIM J, KIM H, ROH H, et al. Causes of hyperhomocysteinemia and its pathological significance [J]. Arch Pharm Res, 2018, 41(4): 372-383. [10] SHARMA G S, KUMAR T, SINGH L R. N-homocysteinylation induces different structural and functional consequences on acidic and basic proteins [J]. PLoS One, 2014, 9(12): e116386. [11] CLEOPHAS T J, HORNSTRA N, VAN HOOGSTRATEN B, et al. Homocysteine, a risk factor for coronary artery disease or not? A meta-analysis [J]. Am J Cardiol, 2000, 86(9): 1005-1009. [12] WIERZBICKI A S. Homocysteine and cardiovascular disease: a review of the evidence [J]. Diab Vasc Dis Res, 2007, 4(2): 143-150. [13] HUMPHREY L L, FU R, ROGERS K, et al. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis [J]. Mayo Clin Proc, 2008, 83(11): 1203-1212. [14] 吴畅, 杜萱, 沈倍倍. 高胱氨酸血症与临床疾病 [J]. 实用老年医学, 1999, 13(3): 150-151. [15] CHOI J H, SEO J W, LEE M Y, et al. Association between elevated plasma homocysteine and low skeletal muscle mass in asymptomatic adults [J]. Endocrinol Metab: Seoul, 2022, 37(2): 333-343. [16] WANG C S, WONG T C, DUONG T V, et al. Hyperhomocysteinemia associated with low muscle mass, muscle function in elderly hemodialysis patients: an analysis of multiple dialysis centers [J]. Biomed Res Int, 2019, 2019: 9276097. [17] MCDERMOTT M M, FERRUCCI L, GURALNIK J M, et al. Elevated levels of inflammation, D-dimer, and homocysteine are associated with adverse calf muscle characteristics and reduced calf strength in peripheral arterial disease [J]. J Am Coll Cardiol, 2007, 50(9): 897-905. [18] SWART K M, ENNEMAN A W, VAN WIJNGAARDEN J P, et al. Homocysteine and the methylenetetrahydrofolate reductase 677C-->T polymorphism in relation to muscle mass and strength, physical performance and postural sway [J]. Eur J Clin Nutr, 2013, 67(7): 743-748. [19] GRANIC A, DAVIES K, MARTIN-RUIZ C, et al. Grip strength and inflammatory biomarker profiles in very old adults [J]. Age Ageing, 2017, 46(6): 976-982. [20] SOUMARÉ A, ELBAZ A, DUCROS V, et al. Cross-sectional association between homocysteine and motor function in the elderly [J]. Neurology, 2006, 67(6): 985-990. [21] GERDHEM P, IVASKA K K, ISAKSSON A, et al. Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women [J]. J Bone Miner Res, 2007, 22(1): 127-134. [22] VIDONI M L, PETTEE GABRIEL K, LUO S T, et al. Vitamin B12 and homocysteine associations with gait speed in older adults: the Baltimore Longitudinal Study of Aging [J]. J Nutr Health Aging, 2017, 21(10): 1321-1328. [23] VAN SCHOOR N M, SWART K M, PLUIJM S M, et al. Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons [J]. Eur J Clin Nutr, 2012, 66(2): 174-181. [24] LU B, SHEN L, ZHU H, et al. Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study [J]. BMC Geriatr, 2022, 22(1): 896. [25] LEE W J, PENG L N, LOH C H, et al. Sex-different associations between serum homocysteine, high-sensitivity C-reactive protein and sarcopenia: results from I-Lan Longitudinal Aging Study [J]. Exp Gerontol, 2020, 132: 110832. [26] EGUCHI Y, TOYOGUCHI T, INAGE K, et al. Advanced glycation end products are associated with sarcopenia in older women: aging marker dynamics [J]. J Women Aging, 2021, 33(3): 328-340. [27] MAJUMDER A, SINGH M, BEHERA J, et al. Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury [J]. Am J Physiol Cell Physiol, 2018, 315(5): C609-C622. [28] YAKOVLEVA O V, ZIGANSHINA A R, DMITRIEVA S A, et al. Hydrogen sulfide ameliorates developmental impairments of rat offspring with prenatal hyperhomocysteinemia [J]. Oxid Med Cell Longev, 2018, 2018: 2746873. [29] VEERANKI S, LOMINADZE D, TYAGI S C. Hyperhomocysteinemia inhibits satellite cell regenerative capacity through p38 alpha/beta MAPK signaling [J]. Am J Physiol Heart Circ Physiol, 2015, 309(2): 325-334. [30] CHEN H, VERMULST M, WANG Y E, et al. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations [J]. Cell, 2010, 141(2): 280-289. [31] VEERANKI S, WINCHESTER L J, TYAGI S C. Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications [J]. Biochim Biophys Acta, 2015, 1852(5): 732-741. [32] WINCHESTER L J, VEERANKI S, PUSHPAKUMAR S, et al. Exercise mitigates the effects of hyperhomocysteinemia on adverse muscle remodeling [J]. Physiol Rep, 2018, 6(6): e13637. [33] GIVVIMANI S, NARAYANAN N, ARMAGHAN F, et al. Attenuation of conducted vasodilation in skeletal muscle arterioles during hyperhomocysteinemia [J]. Pharmacology, 2013, 91(5/6): 287-296. [34] LI Z B, KOLLIAS H D, WAGNER K R. Myostatin directly regulates skeletal muscle fibrosis [J]. J Biol Chem, 2008, 283(28): 19371-19378. [35] ATES BULUT E, SOYSAL P, AYDIN A E, et al. Vitamin B12 deficiency might be related to sarcopenia in older adults [J]. Exp Gerontol, 2017, 95: 136-140. [36] KUO H K, LIAO K C, LEVEILLE S G, et al. Relationship of homocysteine levels to quadriceps strength, gait speed, and late-life disability in older adults [J]. J Gerontol A Biol Sci Med Sci, 2007, 62(4): 434-439. [37] LEISHEAR K, FERRUCCI L, LAURETANI F, et al. Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs [J]. J Gerontol A Biol Sci Med Sci, 2012, 67(5): 537-543. |
[1] | 戚嘉萤, 殷曈曈, 王芳芳, 张慧, 王丽. 老年人体力活动水平与肌少症发生风险关系的剂量-反应Meta分析[J]. 实用老年医学, 2024, 38(9): 905-910. |
[2] | 梁杉杉, 梁欢, 杨珊, 刘建凤. 老年T2DM病人肌少症发生与颈动脉粥样硬化的相关性研究[J]. 实用老年医学, 2024, 38(8): 826-830. |
[3] | 汪月, 李振光, 李梦凡, 张金彪, 齐笑笑. 肌少症与老年人认知功能障碍相关发病机制的研究进展[J]. 实用老年医学, 2024, 38(8): 857-861. |
[4] | 杜雨恬, 廖欣怡, 张素琼, 石磊, 程道梅. 老年H型高血压病人合并肌少症情况及其影响因素研究[J]. 实用老年医学, 2024, 38(7): 665-668. |
[5] | 史岚平, 刘俊松, 王赎, 刘焕兵. 肌少症与心力衰竭和心肌细胞的相关性研究[J]. 实用老年医学, 2024, 38(7): 743-747. |
[6] | 张要田, 周勇, 王军宝, 马昌宝. 老年自发性脑出血病人早期神经功能恶化的危险因素研究[J]. 实用老年医学, 2024, 38(6): 568-571. |
[7] | 周灵杉, 张海燕, 骆颖, 敖小君, 刘蓉, 杨渊, 乔成栋. 老年肌少症人群中血浆褪黑素水平变化的临床分析[J]. 实用老年医学, 2024, 38(5): 465-437. |
[8] | 王超, 陈晓君. 热带气候对东北地区老年原发性高血压病人血压、外周血microRNA-146a及Hcy的影响[J]. 实用老年医学, 2024, 38(5): 470-437. |
[9] | 王金涛, 胡坚. 老年人2型糖尿病与肌少症的关系研究进展[J]. 实用老年医学, 2024, 38(5): 529-437. |
[10] | 初丽敏, 黄芩, 魏唯, 王欢欢, 马丽霞. 老年髋关节骨折病人术后恢复水平与肌少症的相关性[J]. 实用老年医学, 2024, 38(3): 270-272. |
[11] | 姚翠, , 丁玲玉, 胡洁蔓, 孙跃明. 绝对握力与相对握力对老年结直肠癌病人术后并发症的预测价值[J]. 实用老年医学, 2024, 38(3): 317-321. |
[12] | 唐泽丽, 李娟, 田芳, 唐欢, 颜欢, 李雨洁. 肌少症与口腔功能相关性的研究进展[J]. 实用老年医学, 2024, 38(10): 1074-1077. |
[13] | 张飞, 李毛毛, 李铭麟, 王佳贺. 人工智能在肌少症中的应用研究进展[J]. 实用老年医学, 2024, 38(1): 3-6. |
[14] | 周艳雯, 李秀芬, 张长明. 线粒体功能障碍相关分子机制在肌少症发病过程中的作用研究进展[J]. 实用老年医学, 2024, 38(1): 72-76. |
[15] | 尹成淑, 孟晓萍, 曹振东, 宗春光, 李军, 王璐, 李伟, 王淼. 老年冠心病患者血清同型半胱氨酸及超敏 C反应蛋白水平与冠脉病变程度的关系[J]. 实用老年医学, 2016, 30(2): 139-. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||
|