血清25(OH)D水平与老年高血压病人血脂异常及心脑血管事件的相关性研究

doi:10.3969/j.issn.1003-9198.2023.09.015

摘要/Abstract

摘要： 目的研究老年高血压病人血清25-羟基维生素D[25(OH)D]水平与血脂异常及相关心脑血管事件风险的关系。方法选取梧州市工人医院309例老年高血压病人的临床资料进行回顾性分析。根据血清25(OH)D水平分为缺乏组(≤20 ng/mL,96例)、不足组(＞21～29 ng/mL,108例)、充足组(≥29 ng/mL,105例)。收集3组FPG、餐后2 h血糖(2hPG)、HbA1c、24 h平均收缩压(24hSBP)、24 h平均舒张压(24hDBP)、TC、TG、HDL-C、LDL-C等临床资料,记录血脂异常及心脑血管事件发生率,分析25(OH)D与血脂异常及心脑血管事件风险的相关性。结果缺乏组血清HDL-C水平低于不足组、充足组(P＜0.05),24hSBP、TC、TG、LDL-C水平高于不足组、充足组,且不足组TC、TG、LDL-C水平高于充足组(P＜0.05)。缺乏组血脂异常、心脑血管事件发生率高于不足组及充足组(P＜0.05)。25(OH)D水平与TC、TG、LDL-C水平及血脂异常发生率、心脑血管事件发生率呈负相关(r=-0.281、-0.342、-0.189、-0.231、-0.229,P均＜0.05),与HDL-C水平呈正相关(r=0.193,P=0.008)。结论老年高血压病人25(OH)D水平与血脂异常及心脑血管事件风险有关,25(OH)D缺乏病人血脂异常加重,且心脑血管事件风险增高。

关键词: 高血压, 血清25-羟基维生素D, 血脂异常, 心脑血管事件

Abstract: Objective To study the relationship of serum 25-hydroxyvitamin D[25(OH)D] level with dyslipidemia and the risk of related cardio-cerebrovascular events in the elderly hypertensive patients. Methods The clinical data of 309 elderly hypertensive patients in Wuzhou Workers' Hospital were collected and analyzed retrospectively. According to the serum 25(OH)D level, the patients were divided into deficient group (≤ 20 ng/mL, n=96), inadequate group (＞21-29 ng/mL, n=108), and adequate group (＞29 ng/mL, n=105). The serum levels of 25(OH)D, fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), 24-hour mean systolic blood pressure (24hSBP), 24-hour mean diastolic blood pressure (24hDBP), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were detected, and the incidence of dyslipidemia and cardio-cerebrovascular events were recorded, The correlation of 25(OH)D with dyslipidemia and the risk of cardio-cerebrovascular events were analyzed. Results The level of serum HDL-C was lower, and the levels of 24hSBP,TC,TG and LDL-C were higher in the deficient group than those in the inadequate group and the adequate group (P<0.05). The level of 25(OH)D was negatively correlated with the level of TC, TG, LDL-C, the incidence rates of dyslipidemia and cardio-cerebrovascular events (r=-0.281, -0.342, -0.189, -0.231, -0.229, all P<0.05), and positively correlated with the level of HDL-C (r=0.193,P=0.008). Conclusions The level of 25(OH)D in the elderly hypertensive patients is associated with the risk of dyslipidemia and cardio-cerebrovascular events. The patients with 25(OH)D deficiency are prone to suffering from dyslipidemia and increased cardio-cerebrovascular events risk.

Key words: hypertension, serum 25-hydroxyvitamin D, dyslipidemia, cardio-cerebrovascular events

中图分类号:

R 544.1

陈冬云, 何国欢, 彭军. 血清25(OH)D水平与老年高血压病人血脂异常及心脑血管事件的相关性研究[J]. 实用老年医学, 2023, 37(9): 925-928.

CHEN Dong-yun, HE Guo-huan, PENG Jun. Correlation of serum 25(OH)D level with blood lipid dyslipidemia and cardio-cerebrovascular events in elderly patients with hypertension[J]. Practical Geriatrics, 2023, 37(9): 925-928.

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