实用老年医学 ›› 2023, Vol. 37 ›› Issue (6): 595-598.doi: 10.3969/j.issn.1003-9198.2023.06.014

• 临床研究 • 上一篇    下一篇

中度有氧运动对老年抑郁症病人5-羟色胺、去甲肾上腺素水平及自主神经功能的干预效果研究

张易, 郑素珍, 杨丽薇, 林强   

  1. 643020 四川省自贡市,自贡市精神卫生中心检验科
  • 收稿日期:2022-08-22 出版日期:2023-06-20 发布日期:2023-06-30
  • 通讯作者: 林强,Email:kulinqiang@126.com
  • 基金资助:
    自贡市重点科技计划(2021YLSF23)

Effect of moderate aerobic exercise on the levels of serotonin, norepinephrine and autonomic function in elderly patients with depression

ZHANG Yi, ZHENG Su-zhen, YANG Li-wei, LIN Qiang   

  1. Clinical Laboratory, Zigong Mental Health Center, Zigong 643020, China
  • Received:2022-08-22 Online:2023-06-20 Published:2023-06-30
  • Contact: LIN Qiang, Email: kulinqiang@126.com

摘要: 目的 分析中度有氧运动对老年抑郁症病人5-羟色胺(5-HT)、去甲肾上腺素(NE)水平的影响及对自主神经功能的干预效果。 方法 选取2020年1月至2021年6月于我院就诊的100例老年抑郁症病人为研究对象,根据交替分组法分为对照组和观察组,每组各50例。对照组给予帕罗西汀治疗,观察组在对照组的基础上给予中度有氧运动,共12周。比较2组干预前后5-HT、NE水平,低频带(LF)、高频带(HF)、LF/HF比值、抑郁自评量表(SDS)、MMSE评分以及干预效果。 结果 2组病人干预后5-HT、NE水平均升高,且观察组高于对照组,差异有统计学意义(P<0.01)。干预后,2组LF、LF/HF水平较干预前上升,且观察组LF、LF/HF水平高于对照组,差异有统计学意义(P<0.01)。2组病人干预后SDS评分均降低,MMSE评分均升高,且观察组改善更明显(P<0.01)。观察组干预总有效率高于对照组(P<0.05)。 结论 老年抑郁症病人采取中度有氧运动干预可以改善其5-HT、NE水平,且对病人自主神经功能具有积极改善作用。

关键词: 有氧运动, 抑郁症, 5-羟色胺, 去甲肾上腺素, 自主神经功能

Abstract: Objective To analyze the intervention effect of moderate aerobic exercise on the levels of serotonin (5-HT) and norepinephrine (NE) and autonomic function in the elderly patients with depression. Methods A total of 100 elderly patients with depression treated in our hospital from January 2020 to June 2021 were enrolled in this study, and were divided into the control group and the observation group according to the alternating grouping method, with 50 cases in each group. The control group received paroxetine, and the observation group received moderate aerobic exercise based on the control group for 12 weeks. The levels of 5-HT, NE, low frequency band (LF), high frequency band (HF), LF/HF ratio, the scores of self-rating depression scale (SDS) and Mini-mental State Examination (MMSE) and the intervention effect of the two groups were observed and compared. Results After intervention, the levels of 5-HT, NE, LF, LF/HF ratio and the MMSE score in the two groups increased significantly, especially in the observation group (P<0.01), and the SDS scores of the two groups decreased significantly, especially in the observation group (P<0.01). The total effective rate of the observation group was higher than that of the control group (P<0.05). Conclusions Moderate aerobic exercise intervention can improve the levels of 5-HT and NE, and has a positive effect on the autonomic nervous function in the elderly patients with depression.

Key words: aerobic exercise, depression, serotonin, norepinephrine, autonomic function

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