首发老年抑郁症病人睡眠纺缍波与抑郁、焦虑和认知功能的关系

doi:10.3969/j.issn.1003-9198.2024.05.017

摘要/Abstract

摘要： 目的分析首发老年抑郁症病人睡眠纺缍波(sleep spindle, SS)与抑郁、焦虑和认知功能的关系。方法回顾性选取本院2021年1月至2022年1月接诊的40例首发老年抑郁症病人为老年组,40例青中年抑郁症病人为青中年组,40例老年健康体检者为健康组,比较3组SS缺失率、异常率、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)-17评分、MoCA评分的差异。分析不同性别、不同认知功能亚组SS缺失率、异常率。结果老年组SS缺失率(57.50%)、异常率(62.50%)均高于青中年组(32.50%、2.50%)和健康组(35.00%、2.50%)(P＜0.05)。老年组HAMA评分、HAMD-17评分与青中年组比较差异无统计学意义(P>0.05);老年组、青中年组HAMA评分、HAMD-17评分均高于健康组(P＜0.05)。老年组MoCA评分均低于青中年组和健康组(P＜0.05),青中年组MoCA评分低于健康组(P＜0.05)。老年组不同性别病人SS缺失率比较差异无统计学意义(P>0.05);青中年组女性病人SS缺失率显著低于中青年男性和老年女性病人(P＜0.05)。老年组中认知功能障碍亚组SS缺失率、异常率高于无认知功能障碍亚组(P＜0.05)。结论首发老年抑郁症病人SS缺失率、异常率相对较高,SS与认知功能存在一定的关系。

关键词: 老年抑郁症, 睡眠纺缍波, 焦虑, 抑郁, 认知功能

Abstract: Objective To analyze the relationship of sleep spindles (SS) with depression, anxiety and cognitive function in the elderly patients with first episode of depression. Methods A total of 40 patients with the first episode of geriatric depression admitted to our hospital from January 2021 to January 2022 were retrospectively selected as the elderly group, while 40 young and middle-aged patients with depression were enrolled as the young and middle-aged group, and 40 healthy elderly receiving physical examination were enrolled as the healthy group. The deletional rate and abnormal rate of SS, and the scores of Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) -17 and Montreal Cognitive Function Assessment Scale (MoCA) were compared among the three groups. The deletional rate and abnormal rate of SS were also compared between the different gender and different cognitive function subgroups. Results The SS deletion rate (57.50%) and abnormal rate (62.50%) in the elderly group were higher than those in the young and middle-aged group (32.50%, 2.50%) and the healthy group (35.00%, 2.50%) (P<0.05). HAMA score and HAMD-17 score showed no significant differences between the elderly group and the young and middle-aged group (P>0.05), but they were higher than those in the healthy group (P<0.05). The MoCA score in the elderly group was lowest, followed by the young and middle-aged group and the healthy group (P<0.05). There was no significant difference in the deletional rate of SS between the male and female elderly patients (P>0.05). The SS deletional rate in the young and middle-aged female patients was significantly lower than that in the young and middle-aged male patients and the elderly female patients (P<0.05). The deletional rate and abnormal rate of SS in the patients with cognitive dysfunction were higher than those without cognitive dysfunction in the elderly group (P<0.05). Conclusions The deletion rate and abnormal rate of SS are relatively high in the elderly patients with first episode of depression, and SS is related to cognitive function.

Key words: geriatric depression, sleep spindles, anxiety, depression, cognitive function

中图分类号:

R 479.4

王金朋, 张顺, 张晓娟, 王丽萍, 马文有. 首发老年抑郁症病人睡眠纺缍波与抑郁、焦虑和认知功能的关系[J]. 实用老年医学, 2024, 38(5): 505-437.

WANG Jinpeng, ZHANG Shun, ZHANG Xiaojuan, WANG Liping, MA Wenyou. Relationship of sleep spindles with depression, anxiety with cognitive function in elderly patients with first episode of depression[J]. Practical Geriatrics, 2024, 38(5): 505-437.

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