慢性炎症及端粒长度与阿尔茨海默病病人认知功能的相关性研究

doi:10.3969/j.issn.1003-9198.2022.03.018

实用老年医学 ›› 2022, Vol. 36 ›› Issue (3): 284-287.doi: 10.3969/j.issn.1003-9198.2022.03.018

慢性炎症及端粒长度与阿尔茨海默病病人认知功能的相关性研究

刘雅玲, 潘晓东, 周辰, 束婷婷

210024 江苏省南京市,江苏省省级机关医院(江苏省老年病医院)老年医学科(刘雅玲,潘晓东);中心实验室(束婷婷);
210029 江苏省南京市,江苏省人民医院国家药物临床试验机构(周辰)

收稿日期:2021-04-26 出版日期:2022-03-20 发布日期:2022-03-29
通讯作者: 周辰,Email:jsphkjzc@163.com
基金资助:
江苏省卫健委保健局课题(BJ17027)

Correlation between chronic inflammation, telomere length and cognitive function in patients with Alzheimer′s disease

LIU Ya-ling, PAN Xiao-dong, ZHOU Chen, SHU Ting-ting

LIU Ya-ling, PAN Xiao-dong. Department of Geriatrics; SHU Ting-ting. Department of Central Laboratory, Jiangsu Province Geriatric Hospital, Nanjing 210024, China;
ZHOU Chen. Department of Drug Clinical Trial Laboratory, Jiangsu Province Hospital, Nanjing 210024, China

Received:2021-04-26 Online:2022-03-20 Published:2022-03-29

摘要/Abstract

摘要： 目的探讨炎症指标hs-CRP及端粒长度(TL)与AD病人认知功能的相关性,比较不同TL下认知量表各认知域损害特点。方法选择老年病人共135例,分为正常对照组(NC组,n=49)和AD组(n=86),采集人口学及一般临床资料,抽取静脉血检测hs-CRP水平,提取外周血白细胞DNA测定TL,对入组人群评估MoCA评分。比较2组hs-CRP、TL、认知功能等方面的差异,并进一步将AD组按照TL三分位数进行分组,分析各亚组认知域之间的差异。结果 AD组TL短于NC组(P<0.01),而hs-CRP水平高于NC组(P<0.05)。2组年龄、教育年限、DBP、HbA1c、Hcy、MoCA评分差异有统计学意义。Logistic回归分析显示hs-CRP、血Hcy、TL缩短是AD的独立危险因素。AD病人中短端粒组较长端粒组在视空间与执行力、注意力、计算能力、抽象和记忆力方面的认知损害更明显。结论慢性炎症、TL缩短是AD的可能危险因素,TL与认知域损害可能存在线性关系。

关键词: 端粒长度, 阿尔茨海默病, 认知功能, 炎症

Abstract: Objective To investigate the relationship of high-sensitivity C-reactive protein(hs-CRP) and telomere length(TL) with cognitive function in the patients with Alzheimer′s disease (AD), and to investigated the characteristics of cognitive impairment in the patients with different TL. Methods A total of 135 elderly patients were involved and divided into normal control group (NC group, n=49) and AD group (n=86). Demographic and general clinical data were collected. Venous blood was extracted to measure hs-CRP, and peripheral blood leukocyte DNA was extracted to measure TL. The score of Montreal Cognitive Assessment (MoCA) was used to evaluate the level of cognitive function. The levels of hs-CRP and TL were compared between the two groups. The AD patients were further categoried into three subgroups by TL, and the MoCA scores were compared between the subgroups. Results The level of TL in AD group was significantly shorter than that in NC group(P<0.01), while the level of hs-CRP was higher (P<0.05). Binary Logistic regression analysis showed that hs-CRP, serum homocysteine and shortening TL were the independent risk factors for AD. In the AD group, the patients with short telomere presented with more serious cognitive impairment in visual space, executive ability, attention, calculation ability, abstraction and memory compared with the patients with long telomere. Conclusions TL shows linear correlation with cognitive dysfunction in AD patients.

Key words: telomere length, Alzheimer′s disease, cognitive function, inflammation

中图分类号:

R 749.16

刘雅玲, 潘晓东, 周辰, 束婷婷. 慢性炎症及端粒长度与阿尔茨海默病病人认知功能的相关性研究[J]. 实用老年医学, 2022, 36(3): 284-287.

LIU Ya-ling, PAN Xiao-dong, ZHOU Chen, SHU Ting-ting. Correlation between chronic inflammation, telomere length and cognitive function in patients with Alzheimer′s disease[J]. Practical Geriatrics, 2022, 36(3): 284-287.

参考文献

[1] KOTA L N, BHARATH S, PURUSHOTTAM M, et al. Reduced telomere length in neurodegenerative disorders may suggest shared biology[J]. J Neuropsychiatry Clin Neurosci, 2015, 27(2):e92-e96.
[2] MA F, LV X, DU Y, et al. Association of leukocyte telomere length with mild cognitive impairment and Alzheimer’s disease: role of folate and homocysteine[J]. Dement Geriatr Cogn Disord, 2019, 48(1/2):56-67.
[3] CALSOLARO V, EDISON P. Neuroinflammation in Alzheimer’s disease: current evidence and future directions[J]. Alzheimers Dement, 2016, 12(6):719-732.
[4] CAWTHON R M. Telomere measurement by quantitative PCR[J]. Nucleic Acids Res, 2002, 30(10):e47.
[5] 曹东维. 定量聚合酶链反应对系膜细胞TL的测定研究[J]. 南通大学学报(医学版), 2006, 26(2):108-110.
[6] FOSSEL M. A unified model of dementias and age-related neurodegeneration[J]. Alzheimers Dement, 2020, 16(2):365-383.
[7] PALMOS A B, DUARTE R R R, SMEETH D M, et al. Telomere length and human hippocampal neurogenesis[J]. Neuropsychopharmacology, 2020, 45(13):2239-2247.
[8] FORERO D A, GONZÁLEZ-GIRALDO Y, LÓPEZ-QUINTERO C, et al. Meta-analysis of telomere length in Alzheimer’s disease[J]. J Gerontol A Biol Sci Med Sci, 2016, 71(8):1069-1073.
[9] FANI L, HILAL S, SEDAGHAT S, et al. Telomere length and the risk of Alzheimer’s disease: The Rotterdam Study[J]. J Alzheimers Dis, 2020, 73(2):707-714.
[10] McGEER E G, McGEER P L. Neuroinflammation in Alzheimer’s disease and mild cognitive impairment: a field in its infancy[J]. J Alzheimers Dis, 2010, 19(1):355-361.
[11] HENEKA M T, O’BANION M K, TERWEL D, et al. Neuroinflammatory processes in Alzheimer’s disease[J]. J Neural Transm (Vienna), 2010, 117(8):919-947.
[12] GONG C, WEI D, WANG Y, et al. A Meta-analysis of C-reactive protein in patients with Alzheimer′s disease[J]. Am J Alzheimers Dis Other Demen, 2016, 31(3):194-200.
[13] DUONG T, NIKOLAEVA M, ACTON P J. C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer′s disease[J]. Brain Res, 1997, 749(1):152-156.
[14] SONG I U, CHUNG S W, KIM Y D, et al. Relationship between the hs-CRP as non-specific biomarker and Alzheimer′s disease according to aging process[J]. Int J Med Sci, 2015, 12(8):613-617.
[15] SCARABINO D, BROGGIO E, GAMBINA G, et al. Leukocyte telomere length in mild cognitive impairment and Alzheimer′s disease patients[J]. Exp Gerontol, 2017, 98:143-147.
[16] LEVSTEK T, KOZJEK E, DOLžAN V, et al. Telomere attrition in neurodegenerative disorders[J]. Front Cell Neurosci, 2020, 14:219.
[17] MAHONEY E R, DUMITRESCU L, SETO M, et al. Telomere length associations with cognition depend on Alzheimer′s disease biomarkers[J]. Alzheimers Dement (N Y), 2019, 5:883-890.
[18] MORLEY J E. An Overview of cognitive impairment[J]. Clin Geriatr Med, 2018, 34(4):505-513.

慢性炎症及端粒长度与阿尔茨海默病病人认知功能的相关性研究

Correlation between chronic inflammation, telomere length and cognitive function in patients with Alzheimer′s disease

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