实用老年医学

实用老年医学 ›› 2022, Vol. 36 ›› Issue (3): 237-239.doi: 10.3969/j.issn.1003-9198.2022.03.006

• 临床研究 • 上一篇    下一篇

老年住院病人认知障碍与冠心病的关系研究

刘颖, 杨继红, 施红, 李晶, 金莹, 周晋萌, 王慧, 黄家顺, 沈姞, 刘洋   

  1. 100730 北京市,北京医院老年医学科,国家老年医学中心,中国医学科学院老年医学研究院(刘颖,施红,李晶,周晋萌,黄家顺,沈姞,刘洋);肾内科(杨继红,王慧);心理检查室(金莹);
    100006 北京市,中国医学科学院北京协和医学院研究生院(刘颖,杨继红,周晋萌,黄家顺)
  • 收稿日期:2021-04-14 出版日期:2022-03-20 发布日期:2022-03-29
  • 通讯作者: 杨继红,Email:yangjihong3078@bjhmoh.cn
  • 基金资助:
    北京医学奖励基金资助项目(YXJL-2017-0206-0054)

Association between cognitive impairment and coronary heart disease in elderly inpatients

LIU Ying, YANG Ji-hong, SHI Hong, LI Jing, JIN Ying, ZHOU Jin-meng, WANG Hui, HUANG Jia-shun, SHEN Ji, LIU Yang   

  1. LIU Ying, SHI Hong, LI Jing, ZHOU Jin-meng, HUANG Jia-shun, SHEN Ji, LIU Yang. Department of Geriatrics; YANG Ji-hong, WANG Hui. Department of Nephrology; JIN Ying. Department of Neuropsychological Examination Room, Beijing Hospital, National Center of Gerontology, Beijing 100730, China;
    LIU Ying, YANG Ji-hong, ZHOU Jin-meng, HUANG Jia-shun. Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100006, China
  • Received:2021-04-14 Online:2022-03-20 Published:2022-03-29

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摘要： 目的 探索老年住院病人认知障碍与冠心病的关系。 方法 选取678例研究对象,根据是否患冠心病将研究对象分为冠心病组(n=203)与非冠心病组(n=478)。采用MoCA、MMSE对认知状态进行评估,采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(24项版)(HAMD-24评分)对焦虑抑郁状态进行评估,采用Barthel指数对日常生活活动能力(ADL)进行评估。采用Logistic回归分析冠心病的影响因素。 结果 冠心病组MoCA、MMSE、Barthel指数低于非冠心病组,而HAMA评分、HAMD评分高于非冠心病组,差异具有统计学意义(P＜0.05)。多因素Logistic回归提示, MoCA评分高是冠心病的保护因素(OR=0.962,95%CI:0.931~0.994),高龄(OR=1.031,95%CI:1.004~1.058)、HAMA评分高(OR=1.042,95%CI:1.014~1.071)、高血压病程长(OR=1.024,95%CI:1.010~1.038)、糖尿病病程长(OR=1.036,95%CI:1.013~1.060)是冠心病的危险因素(P<0.05)。 结论 老年住院病人的冠心病可能与认知障碍、焦虑状态有关。

关键词: 老年住院病人, 认知障碍, 焦虑, 抑郁, 冠心病

Abstract: Objective To explore the association of cognitive impairment and coronary heart disease(CHD) in the elderly inpatients. Methods A total of 678 elderly patients were enrolled in this study, and were divided into CHD group (n=203) and non-CHD group (n=478). The cognitive function was assessed by Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE); Depression was evaluated by Hamilton Depression Scale (HAMD), and anxiety was evaluated by Hamilton Anxiety Scale (HAMA); Barthel index was used to assess the activities of daily living (ADL). Multivariate Logistic regression analysis was used to analyze the risk factors of CHD. Results The scores of MoCA, MMSE and Barthel index in CHD group were lower than those in non-CHD group, while the scores of HAMA and HAMD were higher than those in non-CHD group (P<0.05). Multivariate Logistic regression analysis showed that higher MoCA score was the protective factor of CHD (OR=0.962, 95% CI: 0.931-0.994) (P<0.05), and older age (OR=1.031, 95% CI: 1.004-1.058), higher HAMA score (OR=1.042, 95% CI: 1.014-1.071), longer duration of hypertension (OR=1.024, 95% CI: 1.010-1.038) and longer duration of diabetes (OR=1.036, 95% CI: 1.013-1.060) were the risk factors of CHD. Conclusions The development of CHD in the elderly inpatients may be related to old age, long course of hypertension, long course of diabetes, anxiety and cognitive impairment.

Key words: elderly inpatients, cognitive impairment, anxiety, depression, coronary heart disease

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