帕金森病相关快速眼动睡眠行为障碍的研究进展

doi:10.3969/j.issn.1003-9198.2026.02.019

摘要/Abstract

摘要： 快速眼动睡眠行为障碍(rapid eye movement sleep behavior disorder,RBD)是PD常见的睡眠障碍类型,对患者的生活质量有重大影响。RBD在老年人群中发病率高,并且可以作为神经退行性疾病的前驱标志。与非RBD的PD患者相比,PD-RBD患者可能表现出更严重的运动和非运动症状,以及更严重的自主神经功能障碍,病程发展更快,预后效果更差。本文围绕PD-RBD的流行病学、临床特征、病理生理学、评估和治疗等方面的研究进展进行综述,指出未来的临床诊疗工作需建立PD-RBD多学科联合评估体系,加强RBD人群健康管理,以便尽早识别及评估病情,延缓疾病进展,降低PD负担。

关键词: 帕金森病, 快速眼动睡眠行为障碍, 睡眠障碍, 神经系统退行性疾病

Abstract: Rapid eye movement sleep behavior disorder (RBD) is a common type of sleep disorders in Parkinson’s disease (PD) and significantly impacts patients’ quality of life. RBD has a high prevalence in the elderly population, and serves as a prodromal marker of neurodegenerative diseases. Compared with PD patients without RBD, PD-RBD patients may show more severe motor and non-motor symptoms, more severe autonomic dysfunction, faster disease progression, and worse prognosis. This article reviews recent advances in the epidemiology, clinical characteristics, pathophysiology, assessment, and management of PD-RBD. We recommend that it is necessary to establish a multidisciplinary evaluation system for PD-RBD, and strengthen the health management of RBD population, so as to identify and evaluate the disease as early as possible, delay the progression of the disease, and reduce the burden of PD.

Key words: Parkinson’s disease, rapid eye movement sleep behavior disorder, sleep disorders, neurodegenerative diseases

中图分类号:

R 742.5

胡月, 汤小佳, 徐俊. 帕金森病相关快速眼动睡眠行为障碍的研究进展[J]. 实用老年医学, 2026, 40(2): 201-205.

HU Yue, TANG Xiaojia, XU Jun. Research progress of Parkinson’s disease-related rapid eye movement sleep behavior disorder[J]. Practical Geriatrics, 2026, 40(2): 201-205.

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