CONUT评分对Ⅱ/Ⅲ期老年结肠癌病人术后辅助化疗耐受性及预后的预测研究

doi:10.3969/j.issn.1003-9198.2025.03.006

实用老年医学 ›› 2025, Vol. 39 ›› Issue (3): 241-244.doi: 10.3969/j.issn.1003-9198.2025.03.006

CONUT评分对Ⅱ/Ⅲ期老年结肠癌病人术后辅助化疗耐受性及预后的预测研究

魏晓为, 张琳珠, 张娟, 周琎

210006 江苏省南京市,南京市第一医院肿瘤内科(魏晓为,张娟);普外科(周琎);211166 江苏省南京市,南京医科大学(张琳珠)

收稿日期:2024-10-25 出版日期:2025-03-20 发布日期:2025-04-03
通讯作者: 周琎,Email:georgenjmu@163.com
基金资助:
吴阶平基金会课题(320.6750.2022-22-9);江苏省自然科学基金资助项目(BK20231127)

Predictive effect of CONUT score on tolerance of postoperative adjuvant chemotherapy and prognosis in elderly patients with stage Ⅱ/Ⅲ colon cancer

WEI Xiaowei, ZHANG Linzhu, ZHANG Juan, ZHOU Jin

Department of Oncology(WEI Xiaowei,ZHANG Juan); Department of General Surgery(ZHOU Jin), Nanjing First Hospital, Nanjing 210006, China; Nanjing Medical University, Nanjing 211166, China(ZHANG Linzhu)

Received:2024-10-25 Online:2025-03-20 Published:2025-04-03
Contact: ZHOU Jin, Email:georgenjmu@163.com

摘要/Abstract

摘要： 目的探讨CONUT评分系统在Ⅱ/Ⅲ期老年结肠癌病人术后辅助化疗中的预测价值。方法回顾性分析2018年1月至2022年1月于南京市第一医院行结肠癌术后辅助化疗的86例病人资料,根据术前CONUT评分分为低CONUT组和高CONUT组。分析并比较2组病人临床特征、化疗依从性及并发症,并进一步分析生存预后。结果高CONUT组Ⅲ/Ⅳ度中性粒细胞缺乏症发生率显著高于低CONUT组(P<0. 05),而且化疗延迟天数较低CONUT组显著延长,差异有统计学意义(P<0. 05)。生存分析显示,高CONUT组病人累积无病生存期(DFS)和总生存期(OS)明显差于低CONUT组。结论 CONUT评分可用于协助评估老年结肠癌病人术后辅助化疗反应以及临床预后。

关键词: CONUT评分, 老年人, 结肠癌, 辅助化疗, 预后

Abstract: Objective To explore the predictive value of CONUT scoring system in the elderly patients with stage Ⅱ/Ⅲ colon cancer who received postoperative adjuvant chemotherapy. Methods The data of 86 patients who underwent postoperative adjuvant chemotherapy for colon cancer in Nanjing First Hospital from January 2018 to January 2022 were retrospectively analyzed and divided into low CONUT group and high CONUT group according to the preoperative CONUT score. The clinical characteristics, chemotherapy compliance and complications were compared between the two groups, and the survival prognosis was further analyzed. Results The incidence rate of grade Ⅲ/Ⅳ neutrophil deficiency was significantly higher in the high CONUT group than that in the low CONUT group (P<0.05), and the days of chemotherapy delay was significantly longer than that in the low CONUT group (P<0.05). Survival analysis showed that the patients in the high CONUT group had significantly worse disease free survival (DFS) and overall survival (OS) than those in the low CONUT group (P<0.05). Conclusions The CONUT score can be used to assist in evaluating the response to postoperative adjuvant chemotherapy and clinical prognosis in the elderly patients with colon cancer.

Key words: controlling nutritional status score, aged, colon cancer, adjuvant chemotherapy, prognosis

中图分类号:

R 735.35

魏晓为, 张琳珠, 张娟, 周琎. CONUT评分对Ⅱ/Ⅲ期老年结肠癌病人术后辅助化疗耐受性及预后的预测研究[J]. 实用老年医学, 2025, 39(3): 241-244.

WEI Xiaowei, ZHANG Linzhu, ZHANG Juan, ZHOU Jin. Predictive effect of CONUT score on tolerance of postoperative adjuvant chemotherapy and prognosis in elderly patients with stage Ⅱ/Ⅲ colon cancer[J]. Practical Geriatrics, 2025, 39(3): 241-244.

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CONUT评分对Ⅱ/Ⅲ期老年结肠癌病人术后辅助化疗耐受性及预后的预测研究

Predictive effect of CONUT score on tolerance of postoperative adjuvant chemotherapy and prognosis in elderly patients with stage Ⅱ/Ⅲ colon cancer

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