老年人血清肌酐/胱抑素C比值和躯体功能的相关性研究

doi:10.3969/j.issn.1003-9198.2025.03.004

实用老年医学 ›› 2025, Vol. 39 ›› Issue (3): 232-235.doi: 10.3969/j.issn.1003-9198.2025.03.004

老年人血清肌酐/胱抑素C比值和躯体功能的相关性研究

周锴雯, 赖飘, 王敏红, 程若熙, 杨丽君, 翁晓芬, 朱耿超, 张俐

215001 江苏省苏州市,南京医科大学附属苏州医院老年医学科

收稿日期:2024-06-21 出版日期:2025-03-20 发布日期:2025-04-03
通讯作者: 张俐,Email:zhangli0123@126.com
基金资助:
江苏省卫生健康发展研究中心课题(JSHD2022061);苏州市临床重点病种诊疗技术专项项目(LCZX201911)

Correlation between serum creatinine-to-cystatin C ratio and physical performance in elderly people

ZHOU Kaiwen, LAI Piao, WANG Minhong, CHENG Ruoxi, YANG Lijun, WENG Xiaofen, ZHU Gengchao, ZHANG Li

Department of Geriatrics, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215001, China

Received:2024-06-21 Online:2025-03-20 Published:2025-04-03
Contact: ZHANG Li, Email: zhangli0123@126.com

摘要/Abstract

摘要： 目的探究社区老年人群血清肌酐/胱抑素C比值和躯体功能的相关性。方法选择在社区进行年度体检的老年人203例为研究对象进行横断面调查,所有老年人完成简易体能测量表(SPPB)评定,并根据SPPB评分结果分为躯体功能减退组(0~9分)和躯体功能正常组(10~12分)。比较2组间一般资料的差异。采用Spearman相关分析和二元logistic回归分析探讨血清肌酐/胱抑素C比值和躯体功能的相关性。结果躯体功能减退组的年龄、5次起坐时间、Hb、总胆红素、尿素氮和胱抑素C水平均高于躯体功能正常组(P＜0.05)。躯体功能正常组的握力、步速、四肢骨骼肌指数(ASMI)、维生素D水平、血清肌酐/胱抑素C比值、游离三碘甲状腺原氨酸水平均高于躯体功能减退组(P＜0.05)。Spearman相关分析显示,血清肌酐/胱抑素C比值与握力、步速、ASMI、SPPB评分呈正相关(P<0.01),与5次起坐时间呈负相关(P<0.01)。二元logistic回归分析结果显示,血清肌酐/胱抑素C比值是躯体功能的独立影响因素。结论在社区老年人群血清肌酐/胱抑素C比值与躯体功能减退关系密切,可能是识别躯体功能下降的简易血清学指标。

关键词: 老年人, 血清肌酐/胱抑素C比值, 简易体能测量表, 躯体功能

Abstract: Objective To investigate the correlation between serum creatinine-to-cystatin C ratio and physical performance in the community elderly. Methods A total of 203 cases of elderly people who underwent physical examination in the community were enrolled in this cross-sectional study. All the elderly underwent the assessment of short physical performance battery(SPPB) scale, and they were divided into poor physical function group(0-9 points) and good physical function group(10-12 points) based on the SPPB score. The general data were compared between the two groups. Spearman correlation analysis and binary logistic regression analysis were used to analyze the relationship between serum creatinine-to-cystatin C ratio and physical performance. Results The levels of age, 5-time chair stand test, hemoglobin, bilirubin, urea nitrogen and cystatin C were higher, and the levels of grip strength, pace, appendicular skeletal muscle index(ASMI)score, vitamin D, serum creatinine/cystatin C ratio and ifree triiodothyronine were significantly lower in poor physical performance group than those in good physical performance group(all P<0.05). Spearman correlation analysis showed significant relationship of serum creatinine-to-cystatin C ratio with grip strength, pace, ASMI and SPPB score. Binary logistic regression analysis showed that serum creatinine/cystatin C ratio was the independent influencing factor of physical performance. Conclusions Serum creatinine-to-cystatin C ratio is strongly associated with decreased physical performance in the community elderly. It may serve as a simple serological indicator for identifying the decline in physical performance.

Key words: aged, serum creatinine-to-cystatin C ratio, Short Physical Performance Battery, physical performance

中图分类号:

R 592

周锴雯, 赖飘, 王敏红, 程若熙, 杨丽君, 翁晓芬, 朱耿超, 张俐. 老年人血清肌酐/胱抑素C比值和躯体功能的相关性研究[J]. 实用老年医学, 2025, 39(3): 232-235.

ZHOU Kaiwen, LAI Piao, WANG Minhong, CHENG Ruoxi, YANG Lijun, WENG Xiaofen, ZHU Gengchao, ZHANG Li. Correlation between serum creatinine-to-cystatin C ratio and physical performance in elderly people[J]. Practical Geriatrics, 2025, 39(3): 232-235.

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老年人血清肌酐/胱抑素C比值和躯体功能的相关性研究

Correlation between serum creatinine-to-cystatin C ratio and physical performance in elderly people

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