住院老年病人衰弱综合征与胰岛素样生长因子-1的相关性研究

doi:10.3969/j.issn.1003-9198.2024.05.010

摘要/Abstract

摘要： 目的研究胰岛素样生长因子-1(insulin-like growth factor-1, IGF-1)水平与住院老年病人衰弱综合征的相关性。方法选取2021年3—8月在我科住院的201例老年病人为研究对象,依据衰弱指数(FI)水平将其分为无衰弱组、衰弱前期组、衰弱组,收集病人营养状况、生活能力、合并症等临床资料,检测IGF-1水平,分析衰弱综合征的相关因素。结果 201例病人中,无衰弱的病人占7.46%(15例)、衰弱前期占44.28%(89例)、衰弱占48.26%(97例),3组病人年龄、Barthel指数、营养风险、服药种类、冠心病比例、IGF-1水平比较,差异均有统计学意义(P<0.05);多因素有序Logistic回归分析显示,Barthel指数下降是衰弱的危险因素(OR=1.859, 95%CI:1.103~3.134),IGF-1水平升高是衰弱的保护因素(OR=0.984, 95%CI:0.976~0.992)。偏相关分析显示,IGF-1水平与FI呈负相关(r=-0.241, P＜0.05)。结论住院老年病人衰弱综合征发生率高,Barthel指数下降是衰弱的危险因素,IGF-1水平升高是衰弱的保护因素。

关键词: 衰弱综合征, 衰弱指数, 胰岛素样生长因子-1, 老年人

Abstract: Objective To investigate the correlation between insulin-like growth factor-1 (IGF-1) and frailty syndrome in the hospitalized elderly patients. Methods A total of 201 elderly patients hospitalized in Department of Geriatrics from March to August 2021 were enrolled in this study. According to frailty index (FI), all patients were divided into non-frailty group, pre-frailty group and frailty group. The clinical data such as nutritional status, living ability and comorbidities were collected and the level of IGF-1 was detected, and all parameters were compared among the three groups. The influencinig factors of frailty syndrome were analyzed. Results The proportion of non-frailty, pre-frailty and frailty in 201 cases was 7.46% (15 cases), 44.28% (89 cases) and 48.26% (97 cases), respectively. The differences in age, Barthel index, nutritional risk, types of medication, proportion of coronary heart disease and the level of IGF-1 were statistically significant among the three groups (P＜0.05).Multiple ordered Logistic regression analysis showed that the decline of Barthel index was a risk factor for frailty (OR=1.859, 95%CI:1.103-3.134), and the high level of IGF-1 was a protective factor for frailty (OR=0.984, 95%CI: 0.976-0.992). Partial correlation analysis showed that IGF-1 was negatively correlated with FI (r=-0.241, P<0.05). Conclusions The incidence of frailty is high in hospitalized elderly patients. The decrease of Barthel index is a risk factor for frailty, and the increase of IGF-1 is a protective factor for frailty.

Key words: frailty syndrome, frailty index, insulin-like growth factor-1, aged

中图分类号:

R 592

寇夕, 刘永宏, 董玮, 王华, 王宝梅, 高玉芳. 住院老年病人衰弱综合征与胰岛素样生长因子-1的相关性研究[J]. 实用老年医学, 2024, 38(5): 474-437.

KOU Xi, LIU Yonghong, DONG Wei,WANG Hua, WANG Baomei, GAO Yufang. Correlation between insulin-like growth factor-1 and frailty syndrome in hospitalized elderly patients[J]. Practical Geriatrics, 2024, 38(5): 474-437.

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