术前HALP评分对老年非小细胞肺癌手术病人预后的预测价值

doi:10.3969/j.issn.1003-9198.2022.12.018

实用老年医学 ›› 2022, Vol. 36 ›› Issue (12): 1259-1263.doi: 10.3969/j.issn.1003-9198.2022.12.018

术前HALP评分对老年非小细胞肺癌手术病人预后的预测价值

袁梦依, 王培山, 孟瑞霞, 杨建军, 周成茂, 焦钟雨

453000 河南省新乡市,新乡医学院第四临床学院(袁梦依,焦钟雨);
453000 河南省新乡市,新乡市中心医院(新乡医学院第四临床学院)麻醉科(王培山,孟瑞霞);
450000 河南省郑州市,郑州大学第一附属医院麻醉科(杨建军,周成茂)

收稿日期:2022-01-04 出版日期:2022-12-20 发布日期:2022-11-30
通讯作者: 王培山,Email: wangpeishan_168@126.com
基金资助:
河南医学科技攻关计划项目(2018020936)

Predictive value of preoperative hemoglobin, albumin, lymphocyte and platelet(HALP) score for prognosis of elderly patients with non-small cell lung cancer undergoing surgery

YUAN Meng-yi, WANG Pei-shan, MENG Rui-xia, YANG Jian-jun, ZHOU Cheng-mao, JIAO Zhong-yu

YUAN Meng-yi, JIAO Zhong-yu. The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, China;
WANG Pei-shan, MENG Rui-xia.Department of Anesthesiology, Xinxiang Central Hospital, Xinxiang 453000, China;
YANG Jian-jun, ZHOU Cheng-mao. Department of Anesthesiology,the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China

Received:2022-01-04 Online:2022-12-20 Published:2022-11-30

摘要/Abstract

摘要： 目的探讨术前血红蛋白、白蛋白、淋巴细胞、血小板评分(HALP评分)对老年非小细胞肺癌(NSCLC)手术病人预后的预测价值。方法收集新乡市中心医院2015～2019年老年NSCLC手术病人的临床资料,分析HALP评分对预后的影响。结果单因素Cox回归分析显示,术前HALP评分、△HALP评分、肿瘤TNM分期、肿瘤分化程度、吸烟史、肿瘤部位、白蛋白水平、血红蛋白水平、术后住院时间等与术后总生存期(OS)、无进展生存期(PFS)相关(均P＜0.05)。多因素Cox回归分析显示,术前HALP评分、肿瘤TNM分期、肿瘤分化程度是影响病人OS及PFS的独立影响因素,术前白蛋白水平为病人OS的独立影响因素(均P＜0.05)。结论 HALP评分可作为临床老年NSCLC手术病人术后生存情况的预测指标,辅助进行针对性干预可以改善预后。

关键词: 老年人, 非小细胞肺癌, 营养, 炎症, 免疫, HALP评分

Abstract: Objective To investigate the predictive value of preoperative hemoglobin, albumin, lymphocyte and platelet (HALP) score for the prognosis of the elderly patients with non-small cell lung cancer (NSCLC) undergoing surgery. Methods The clinical data of 270 elderly patients with NSCLC undergoing surgery in Xinxiang Central Hospital from January 2015 to December 2019 were collected, and the predictive value of HALP score for the prognosis was analyzed. Results Univariate Cox regression analysis showed that preoperative HALP score, ΔHALP score, tumor TNM stage, tumor differentiation, smoking history, tumor location, serum albumin level, hemoglobin level and postoperative hospital stay were associated with postoperative overall survival (OS) and progression-free survival (PFS) (all P<0.05). Multivariate Cox regression analysis showed that preoperative HALP score, tumor TNM stage and tumor differentiation were the independent risk factors for OS and PFS, and preoperative serum albumin level was an independent risk factor for OS (all P＜0.05). Conclusions HALP score can be used as a predictor for postoperative survival in the elderly patients with NSCLC after surgery, which could assist clinical targeted intervention to improve prognosis.

Key words: aged, non-small cell lung cancer, nutrition, inflammation, immunity, HALP score

中图分类号:

R734.2

袁梦依, 王培山, 孟瑞霞, 杨建军, 周成茂, 焦钟雨. 术前HALP评分对老年非小细胞肺癌手术病人预后的预测价值[J]. 实用老年医学, 2022, 36(12): 1259-1263.

YUAN Meng-yi, WANG Pei-shan, MENG Rui-xia, YANG Jian-jun, ZHOU Cheng-mao, JIAO Zhong-yu. Predictive value of preoperative hemoglobin, albumin, lymphocyte and platelet(HALP) score for prognosis of elderly patients with non-small cell lung cancer undergoing surgery[J]. Practical Geriatrics, 2022, 36(12): 1259-1263.

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术前HALP评分对老年非小细胞肺癌手术病人预后的预测价值

Predictive value of preoperative hemoglobin, albumin, lymphocyte and platelet(HALP) score for prognosis of elderly patients with non-small cell lung cancer undergoing surgery

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