左心房存储应变对老年心力衰竭病人远期不良预后的预测价值

doi:10.3969/j.issn.1003-9198.2022.10.014

摘要/Abstract

摘要： 目的探讨左心房存储应变对老年心力衰竭(心衰)病人远期不良预后的预测价值。方法前瞻性选取2018年7月至2019年7月承德市中心医院收治的136例年龄≥65岁老年心衰病人为研究对象,随访观察2年,以全因死亡作为不良预后,并以此分为预后不良组和预后良好组,采用多因素Cox回归分析老年心衰病人远期不良预后的影响因素。结果截至随访终点,失访11例,最终125例获得随访,其中42例(33.60%)出现全因死亡(预后不良);83例(66.40%)预后良好。预后不良组与预后良好组左心房容积指数(LAVI)、左心房储备期应变(LARS)、LVEF及N末端B型利钠肽原(NT-proBNP)水平比较,差异具有统计学意义(P<0.01)。多因素Cox回归分析显示,NT-proBNP(HR=1.001,95%CI:1.000～1.002)、LAVI(HR=1.082,95%CI:1.002～1.168)为老年心衰病人远期不良预后的独立危险因素,LVEF(HR=0.944,95%CI:0.893～0.998)、LARS(HR=0.945,95%CI:0.902～0.991)为老年心衰病人远期不良预后的保护因素。ROC曲线分析显示,LARS(AUC=0.847,95%CI:0.772～0.905)对远期不良预后的预测价值高于LVEF(AUC=0.670,95%CI:0.650～0.811)和LAVI(AUC=0.698,95%CI:0.721～ 0.868)。结论 LAVI、LARS、LVEF及NT-proBNP可预测老年心衰病人远期不良预后,LARS是优于LAVI、LVEF的左心房参数。

关键词: 左心房存储应变, 心力衰竭, 老年人, 预后

Abstract: Objective To explore the predictive value of left atrial strain for the long-term poor prognosis of elderly patients with heart failure. Methods A total of 136 elderly patients with heart failure age ≥ 65 years old admitted to Chengde Central Hospital from July 2018 to July 2019 were prospectively selected as the research subjects. The patients were followed up for 2 years. According to the all-cause death results, they were divided into poor prognosis group and good prognosis group. The influencing factors of long-term poor prognosis of the elderly patients with heart failure were analyzed by multivariate Cox regression. Results By the end of the follow-up, 42 cases (33.60%) presented with all-cause death and 83 cases (66.40%) with a good prognosis. There were significant differences in the levels of left atrial volume index (LAVI), left atrial reserve strain (LARS), left ventricular ejection fraction (LVEF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) between poor prognosis group and good prognosis group. Multivariate Cox regression analysis showed that NT-proBNP (HR=1.001, 95%CI: 1.000-1.002) and LAVI (HR=1.082, 95%CI:1.002-1.168) were the independent risk factors of long-term poor prognosis, and LVEF (HR=0.944, 95%CI:0.893-0.998) and LARS (HR=0.945, 95%CI:0.902-0.991) were the protective factors of long-term poor prognosis in the elderly patients with heart failure (all P<0.05). ROC curve analysis showed that the area under curve(AUC) of LARS was higher than that of LVEF and LAVI. Conclusions LAVI, LARS, LVEF and NT-proBNP can predict the long-term poor prognosis of elderly patients with heart failure, and LARS is more valuable than other parameters.

Key words: left atrial strain, heart failure, aged, prognosis

中图分类号:

R541.61

马晓英, 李久民, 钦佩, 刘淼, 金明磊. 左心房存储应变对老年心力衰竭病人远期不良预后的预测价值[J]. 实用老年医学, 2022, 36(10): 1033-1037.

MA Xiao-ying, LI Jiu-min, QIN Pei, LIU Miao, JIN Ming-lei. Predictive value of left atrial strain for long-term poor prognosis of elderly patients with heart failure[J]. Practical Geriatrics, 2022, 36(10): 1033-1037.

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