射血分数保留的老年心力衰竭病人血小板/淋巴细胞比值与左心室舒张功能的相关性分析

doi:10.3969/j.issn.1003-9198.2022.10.007

摘要/Abstract

摘要： 目的研究射血分数保留的老年心力衰竭(HFpEF)病人血小板/淋巴细胞比值(PLR)与左心室舒张功能的相关性。方法共纳入53例老年HFpEF病人,依据二尖瓣口E峰流速与二尖瓣环舒张早期峰值速度比值(E/e')将病人分为低E/e'组(E/e'＜8)、中E/e'组(8≤E/e'≤14)及高E/e'组(E/e'＞14),比较3组病人临床特征、生化指标及心脏超声等相关指标,分析PLR与左心室舒张功能E/e'的相关性。结果低、中、高E/e'组之间年龄、淋巴细胞计数(LY)及PLR差异有统计学意义(P＜0.05),其他指标的差异无统计学意义(P＞0.05)。Spearman相关分析显示,PLR与E/e'呈显著负相关(P＜0.05); LY及年龄与E/e'呈显著正相关(P＜0.05);左心室舒张末期内径(LVDd)及左心室收缩末期内径(LVDs)与PLR呈显著正相关(P＜0.05)。简单线性回归分析显示,PLR对E/e'的影响有统计学意义(F=12.361,P＝0.001),回归方程为E/e'=18.145－0.030×PLR。多元线性回归分析显示,PLR是E/e'的独立影响因素(b=-0.025,t=-2.401,P=0.020)。结论老年HFpEF病人PLR与左心室舒张功能密切相关,PLR越高,E/e'越低。

关键词: 老年人, 射血分数保留的心力衰竭, 血小板/淋巴细胞比值, 左心室舒张功能

Abstract: Objective To study the relationship between platelet-to-lymphocyte ratio (PLR) and left ventricular diastolic function in the elderly patients with heart failure with preserved ejection fraction (HFpEF). Methods A total of 53 elderly patients with HFpEF were enrolled. According to the transmitral flow velocities to mitral annulus tissue velocities ratio in early diastole (E/e'), the patients were divided into low E/e' group (E/e'＜8), middle E/e' group (8≤E/e'≤14) and high E/e' group (E/e'＞14). The clinical characteristics, biochemical indicators, cardiac ultrasound and other related indicators of these patients were detected and compared among the three groups. And the relationship between PLR and E/e' was analyzed. Results There were significant differences in age, lymphocyte count (LY) and PLR among the three groups (P＜0.05), but there were no significant differences in other indicators among the three groups (P＞0.05). Spearman correlation analysis showed that PLR was negatively correlated to E/e' (P＜0.05); LY and age were positively correlated to E/e' (P＜0.05). Left ventricular end-diastolic diameter and left ventricular end-systolic diameter had positive correlation with PLR (P＜0.05). Simple linear regression analysis showed that PLR showed significant effect on E/e' (F=12.361, P＝0.001), and the regression equation can be obtained as E/e'=18.145-0.030×PLR. Multiple linear regression analysis showed that PLR was an independent factor influencing E/e' (b=-0.025, t=-2.401, P=0.020). Conclusions PLR is closely related to the left ventricular diastolic function in the elderly patients with HFpEF.

Key words: aged, heart failure with preserved ejection fraction, platelet-to-lymphocyte ratio, left ventricular diastolic function

中图分类号:

R541.6

刘先玲, 洪牮, 许迪. 射血分数保留的老年心力衰竭病人血小板/淋巴细胞比值与左心室舒张功能的相关性分析[J]. 实用老年医学, 2022, 36(10): 1001-1005.

LIU Xian-ling, HONG Jian, XU Di. Relationship of platelet-to-lymphocyte ratio with left ventricular diastolic function in elderly patients with heart failure with preserved ejection fraction[J]. Practical Geriatrics, 2022, 36(10): 1001-1005.

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