老年子宫内膜癌病人血清热休克蛋白70、内脂素、糖类抗原724水平及临床意义

doi:10.3969/j.issn.1003-9198.2022.06.008

摘要/Abstract

摘要： 目的探究老年子宫内膜癌病人血清热休克蛋白70(HSP70)、内脂素(visfatin)、糖类抗原724(CA724)水平及临床意义。方法选取2018年12月至2021年3月我科收治的老年子宫内膜癌病人125例(子宫内膜癌组),另选取老年健康体检人员100例(对照组),检测并比较2组病人血清HSP70、visfatin、CA724的水平,分析不同病理特征病人血清HSP70、visfatin、CA724水平的差异。采用ROC曲线分析HSP70、visfatin、CA724单独和联合检测对子宫内膜癌的诊断效能。结果子宫内膜癌组血清HSP70水平低于对照组,visfatin、CA724水平高于对照组,差异均有统计学意义(P<0.01)。不同TNM分期、肿瘤组织分化程度、淋巴结转移病人的血清HSP70、visfatin、CA724水平比较,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示:HSP70、visfatin、CA724联合检测诊断子宫内膜癌发生的AUC为0.878,敏感度和特异度分别为0.872和0.824,均高于三者单独检测。结论血清HSP70、visfatin、CA724水平变化与老年子宫内膜癌的发生发展有关,三项指标联合检测有望成为新的辅助诊断老年子宫内膜癌的生物标志物。

关键词: 热休克蛋白70, 内脂素, 糖类抗原724, 子宫内膜癌, 老年人

Abstract: Objective To investigate the serum levels and clinical significance of heat shock protein 70 (HSP70), visfatin and carbohydrate antigen 724 (CA724) in the elderly patients with endometrial cancer. Methods A total of 125 elderly patients with endometrial cancer admitted to our department from December 2018 to March 2021 were selected as endometrial cancer group.Another 100 healthy elderly people were selected as control group.The serum levels of HSP70, visfatin and CA724 were detected and compared between the two groups.The levels of HSP70, visfatin, CA724 of different clinicopathological characteristics groups of the elderly patients with endometrial cancer were compared. The diagnostic efficiency of HSP70, visfatin, CA724 alone and combination of the three indexes for endometrial cancer was analyzed by receiver operating characteristic (ROC) curve. Results The serum level of HSP70 in endometrial cancer group was lower than that in control group, and the serum levels of visfatin and CA724 were higher than those in control group, with statistically significant differences (P<0.01). There were significant differences in serum levels of HSP70, visfatin and CA724 in the patients with different TNM stages, tumor tissue differentiation degree, and lymph node metastasis (P<0.05). ROC curve analysis showed that the combination of HSP70, visfatin and CA724 had an area under the curve of 0.878 for the diagnosis of endometrial cancer, and the sensitivity and specificity was 0.872 and 0.824, respectively, which were higher than the parameters alone. Conclusions The changes of serum HSP70, visfatin and CA724 levels are related to the occurrence and development of endometrial cancer in the elderly. The combined detection of the three indicators is expected to become a new biomarker for predicting and diagnosing endometrial cancer in the elderly.

Key words: heat shock protein 70, visfatin, carbohydrate antigen 724, endometrial cancer, aged

中图分类号:

R 737.33

胡猛, 牛三强, 陈艳, 刘宁. 老年子宫内膜癌病人血清热休克蛋白70、内脂素、糖类抗原724水平及临床意义[J]. 实用老年医学, 2022, 36(6): 580-583.

HU Meng, NIU San-qiang, CHEN Yan, LIU Ning. Clinical significance of heat shock protein 70, visfatin and carbohydrate antigen 724 in elderly patients with endometrial cancer[J]. Practical Geriatrics, 2022, 36(6): 580-583.

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