丹红注射液联合脑苷肌肽治疗老年高血压性脑出血病人的临床研究

doi:10.3969/j.issn.1003-9198.2022.05.013

摘要/Abstract

摘要： 目的探讨丹红注射液联合脑苷肌肽治疗老年高血压性脑出血(HICH)病人的临床疗效及对病人脑血流动力学和血清神经元特异性烯醇化酶(NSE)、超氧化物歧化酶(SOD)、IL-6水平的影响。方法选取2019年7月至2020年7月我院收治的240例HICH老年病人,随机分为观察组和对照组,每组120例。对照组给予脑苷肌肽治疗,观察组在此基础上联合丹红注射液治疗,疗程均为14 d。观察并比较2组临床疗效及安全性,治疗前后患侧大脑中动脉脑血流动力学参数[平均血流速度(V_m)、搏动指数(PI)及阻力指数(RI)]及血清NSE、SOD、IL-6水平的变化情况,并进行统计分析。结果观察组总有效率(92.5%)显著高于对照组(83.3%),差异有统计学意义(P<0.05)。与治疗前相比,2组治疗后NIHSS、日常生活能力(ADL)评分均显著降低(P<0.01),血肿体积显著缩小(P<0.01),且观察组比对照组改善更显著(P<0.01)。2组治疗后患侧大脑中动脉V_m均明显较治疗前加快(P<0.05),PI、RI则显著低于治疗前(P<0.05),且观察组比对照组改善更显著(P<0.05)。2组治疗后血清NSE、IL-6水平均较治疗前显著下降(P<0.01),血清SOD水平均显著上升(P<0.01),且观察组改善更显著(P<0.01)。2组不良反应发生率(7.5%比5.8%)比较,差异无统计学意义(P>0.05)。结论丹红注射液联合脑苷肌肽治疗老年HICH的总体疗效满意,能显著改善患侧脑血流动力学状态和血清NSE、SOD、IL-6水平。

关键词: 高血压性脑出血, 丹红注射液, 脑苷肌肽, 老年人

Abstract: Objective To investigate the clinical efficacy of Danhong injection combined with cerebroside and carnosine in the treatment of hypertensive intracerebral hemorrhage (HICH),and its effect on the levels of cerebral hemodynamics parameters, serum neuron-specific enolase (NSE), superoxide dismutase(SOD) and interleukin-6 (IL-6). Methods A total of 240 HICH patients admitted to our hospital from July 2019 to July 2020 were selected and randomly divided into the observation group and the control group with 120 cases in the each group. The control group was treated with cerebroside and carnosine, and the observation group was treated with Danhong injection additionally. The course of treatment was 14 days in two groups. The clinical efficacy and safety, the cerebral hemodynamic parameters of the affected side middle cerebral artery [mean blood flow velocity (V_m), pulsatility index (PI) and resistance index (RI)], and the serum levels of NSE, SOD, IL-6 before and after treatment in the two groups were observed and compared. Results The total effective rate of the observation group(92.5%) was significantly higher than that of the control group (83.3%),with significant difference between the two groups (P<0.05). Compared with before treatment, the scores of National Institutes of Health Stroke Scale (NIHSS) and activities of daily living (ADL) and the hematoma volume were significantly decreased in both groups after treatment (P<0.05), especially in the observation group (P<0.05). The V_m of the middle cerebral artery on the affected side and the serum level of SOD was significantly increased, and the PI,RI and the serum levels of NSE and IL-6 were significantly decreased in both groups after treatment (P<0.05), especially in the observation group (P<0.05). There was no significant difference in adverse reaction rate between the observation group and the control group (7.5% vs 5.8%, P>0.05). Conclusions Danhong injection combined with cerebroside and carnosine can significantly improve the state of cerebral hemodynamics and the serum levels of NSE, SOD and IL-6 in the elderly patients with HICH.

Key words: hypertensive cerebral hemorrhage, Danhong injection, cerebroside carnosine, aged

中图分类号:

R 743.3

高普, 刘亮, 刘杏棉, 张自豪, 张文亮, 吴志宝. 丹红注射液联合脑苷肌肽治疗老年高血压性脑出血病人的临床研究[J]. 实用老年医学, 2022, 36(5): 487-491.

GAO Pu, LIU Liang, LIU Xing-mian, ZHANG Zi-hao, ZHANG Wen-liang, WU Zhi-bao. Clinical study of Danhong injection combined with cerebroside and carnosine in elderly patients with hypertensive intracerebral hemorrhage[J]. Practical Geriatrics, 2022, 36(5): 487-491.

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