血管生成素样蛋白8联合ABCD-3I评分预测老年短暂性脑缺血病人近期脑梗死的应用价值

doi:10.3969/j.issn.1003-9198.2022.02.020

摘要/Abstract

摘要： 目的探讨血清血管生成素样蛋白8(ANGPTL8)联合ABCD-3I评分预测老年短暂性脑缺血(TIA)病人近期脑梗死的应用价值。方法选取2018年3月至2020年10月期间在我院治疗的老年TIA病人246例,根据病人3个月随访期间是否发生脑梗死分为脑梗死组(32例)和TIA组(214例),比较2组临床基本资料、ABCD-3I评分及血清ANGPTL8水平;采用多因素Logistic回归分析TIA病人近期发生脑梗死的危险因素。结果脑梗死组的年龄,合并高血压、糖尿病的比例,ABCD-3I评分,血清ANGPTL8水平均高于TIA组,差异均有统计学意义(P<0.05);ANGPTL8高表达组的脑梗死发生率明显高于低表达组,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,年龄、高血压病史、糖尿病病史、ABCD-3I评分、血清ANGPTL8水平均是老年TIA病人近期发生脑梗死的危险因素(P<0.05);ROC曲线分析显示,血清ANGPTL8、ABCD-3I评分均可用于预测老年TIA病人近期脑梗死的发生风险,AUC分别为0.757(95%CI:0.666~0.847)、0.765(95%CI:0.684~0.846),二者联合应用可有效提升预测价值,AUC为0.863(95%CI:0.786~0.939)。结论血清ANGPTL8和ABCD-3I评分是老年TIA病人近期发生脑梗死的危险因素,二者可用于临床预测TIA病人近期脑梗死的发生风险。

关键词: 短暂性脑缺血, 脑梗死, 老年人, 血管生成素样蛋白8, ABCD-3I评分

Abstract: Objective To investigate the application value of angiopoitin-like protein 8 (ANGPTL8) combined with ABCD-3I score in predicting short-term cerebral infarction in the elderly patients with transient ischaemic attack (TIA). Methods A total of 246 elderly patients with TIA who were treated in our hospital from March 2018 to October 2020 were selected. The patients were divided into cerebral infarction group (32 cases) and TIA group (214 cases) according to whether they presented with cerebral infarction in 3 months. The clinical data,ABCD-3I score and serum ANGPTL8 level were compared between the two groups. Multiple Logistic regression was conducted to analyze the risk factors of short-term cerebral infarction. Results The age, the incidence rate of hypertension or diabetes mellitus, ABCD-3I score and serum ANGPTL8 level in cerebral infarction group were statistically higher than those in TIA group (P<0.05); The incidence rate of cerebral infarction in the high ANGPTL8 expression group was significantly higher than that in the low expression group (P<0.05); Multivariate Logistic regression analysis showed that age, hypertension, diabetes mellitus, ABCD-3I score and serum ANGPTL8 were risk factors for cerebral infarction in the TIA patients (P<0.05); Receiver operating characteristic curve analysis showed that serum level of ANGPTL8 and ABCD-3I score could be used to predict the risk of cerebral infarction in TIA patients in the near future, and the area under the curve was 0.757 (95% CI: 0.666-0.847) and 0.765 (95% CI: 0.684-0.846), respectively. The combination of the two indexes could effectively improve the predictive value, and the area under the curve was 0.863 (95% CI: 0.786-0.939). Conclusions Serum ANGPTL8 and ABCD-3I score are risk factors for cerebral infarction in the elderly patients with TIA, and they can be used to predict the risk of cerebral infarction.

Key words: transient ischaemic attack, cerebral infarction, aged, angiopoietin-like protein 8, ABCD-3I score

中图分类号:

R 743

啜红斐. 血管生成素样蛋白8联合ABCD-3I评分预测老年短暂性脑缺血病人近期脑梗死的应用价值[J]. 实用老年医学, 2022, 36(2): 188-191.

CHUAI Hong-fei. Application value of serum angiopoietin-like protein 8 combined with ABCD-3I score in predicting short-term cerebral infarction in elderly patients with transient ischaemic attack[J]. Practical Geriatrics, 2022, 36(2): 188-191.

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