实用老年医学

实用老年医学 ›› 2022, Vol. 36 ›› Issue (2): 184-187.doi: 10.3969/j.issn.1003-9198.2022.02.019

• 临床研究 • 上一篇    下一篇

血清瘦素、脂联素及趋化素水平与老年人群骨质疏松相关性研究

梁杰, 崔蕴文, 赵樱   

  1. 830054 新疆维吾尔自治区乌鲁木齐市,新疆医科大学第一附属医院综合内一科(梁杰,崔蕴文);
    830000 新疆维吾尔自治区乌鲁木齐市,新疆维吾尔自治区人民医院全科医疗科(赵樱)
  • 收稿日期:2021-03-03 出版日期:2022-02-20 发布日期:2022-02-28
  • 基金资助:
    新疆维吾尔自治区自然科学基金资助项目(2016D01C303)

Correlation between osteoporosis and serum levels of leptin, adiponectin and chemokine in elderly

LIANG Jie, CUI Yun-wen, ZHAO Ying   

  1. LIANG Jie, CUI Yun-wen. Department of General Medicine, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China;
    ZHAO Ying. Department of General Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, China
  • Received:2021-03-03 Online:2022-02-20 Published:2022-02-28

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摘要： 目的 探讨骨质疏松与血清瘦素、脂联素及趋化素水平的相关性。 方法 选择2016年9月至2019年2月入住我院的72例老年骨质疏松病人作为骨质疏松组,另选取同期于我院体检的65例老年骨量正常者作为对照组。对比分析2组血清瘦素、脂联素及趋化素水平,腰椎L1～4骨密度(BMD)、左侧髋关节BMD及相关生化指标。 结果 骨质疏松组趋化素、脂联素水平高于对照组,瘦素水平低于对照组,差异均有统计学意义(P＜0.05)。相关分析结果显示,骨质疏松组血清趋化素、脂联素均分别与腰椎及髋部BMD呈负相关(r=-0.630, r=-0.569, P<0.01;r=-0.275, r=-0.197, P <0.01),瘦素与腰椎及髋部BMD呈正相关(r=0.428, r=0.332, P<0.05或P <0.01)。多因素Logistic回归分析,校正年龄、性别、BMI后,血清趋化素水平升高可使骨质疏松发生的风险增高(OR=1.25, 95%CI:1.09~1.43),瘦素水平升高使骨质疏松发生的风险降低(OR=0.21, 95%CI:0.07~0.65),脂联素与骨质疏松发生关联不明显(OR=1.03, 95%CI:0.96~1.12)。 结论 血清趋化素水平越高的老年人骨质疏松发生风险越大,可能是潜在的骨质疏松发病危险预测指标。血清瘦素水平与老年人骨质疏松发生风险呈负相关,或许可通过干预以上指标来预防骨质疏松的发生。

关键词: 老年人, 骨质疏松, 骨密度, 瘦素, 脂联素, 趋化素

Abstract: Objective To investigate the correlation between osteoporosis and serum levels of leptin, adiponectin and chemokine in the elderly. Methods A total of 72 elderly patients with osteoporosis were selected as the study subjects who were admitted to our hospital from September 2016 to February 2019, and 65 elderly cases with normal bone mass were selected as control group who underwent physical examination in our hospital during the same period. The serum levels of leptin, adiponectin, chemokine, bone mineral density(BMD) of lumbar 1-4,BMD of left hip joint and related biochemical indexes were detected and compared between the two groups. Results The levels of chemokine and adiponectin in osteoporosis group were higher than those in control group, while the level of leptin was lower than that in control group (P <0.05). Pearson correlation analysis showed that serum levels of chemokine and adiponectin were negatively correlated with BMD of lumbar spine and hip in osteoporosis group (r=-0.630, r=-0.569, P<0.01; r=-0.275, r=-0.197, P<0.01). The level of leptin was positively correlated with BMD of lumbar spine and hip(r=0.428, r=0.332, P<0.05 or P <0.01). Multivariate Logistic regression analysis showed that the serum level of chemokine increased the risk of osteoporosis after adjusting age, sex and body mass index(OR=1.25, 95%CI:1.09-1.43). The level of leptin reduced the risk of osteoporosis(OR=0.21, 95%CI:0.07-0.65). Adiponectin was not associated with osteoporosis obviously(OR=1.03, 95%CI:0.96-1.12). Conclusions The serum level of chemokine is positively correlated with the occurrence of osteoporosis in the elderly, which is a risk factor of osteoporosis and may be a predictor of the potential risk of osteoporosis. The serum level of leptin is negatively correlated with the risk of osteoporosis in the elderly, which may play a protective role in the development of osteoporosis and provide theoretical basis for clinical prevention and treatment of osteoporosis in the elderly.

Key words: aged, osteoporosis, bone mineral density, leptin, adiponectin, chemokine

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