实用老年医学

实用老年医学 ›› 2022, Vol. 36 ›› Issue (2): 142-145.doi: 10.3969/j.issn.1003-9198.2022.02.009

• 临床研究 • 上一篇    下一篇

老年2型糖尿病病人甲状腺功能减退与糖尿病肾病的关系

葛静, 孙心怡, 于茜, 张舒, 缪鋆鋆   

  1. 210029 江苏省南京市,南京中医药大学附属医院内分泌科
  • 收稿日期:2021-08-21 出版日期:2022-02-20 发布日期:2022-02-28
  • 通讯作者: 缪鋆鋆,Email:miaojunjun98@sina.com
  • 基金资助:
    江苏省中医院院级课题(Y2020CX25,Y2020CX20)

Relationship between subclinical hypothyroidism and diabetic nephropathy in elderly patients with type 2 diabetes mellitus

GE Jing, SUN Xin-yi, YU Qian, ZHANG Shu, MIAO Jun-jun   

  1. Department of Endocrinology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China
  • Received:2021-08-21 Online:2022-02-20 Published:2022-02-28

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摘要： 目的 回顾性探究老年T2DM病人甲状腺功能减退与糖尿病肾病(DKD)的相关性。 方法 选择2019～2020年在江苏省中医院内分泌科诊断治疗的老年T2DM病人,根据甲状腺功能分为甲状腺功能正常组(甲功正常组,n=320)和亚临床甲状腺功能减退组(亚甲减组,n=46),比较2组病人的临床资料、生化指标及肾功能。结果 亚甲减组女性病人比例高于甲功正常组(P＜0.05);甲功正常组DKD者185例(57.8%),亚甲减组34例(73.9%),2组间差异有统计学意义(P＜0.05);2组间SBP、DBP及血清TC、TG、LDL-C、HbA1c、尿白蛋白肌酐比值(UACR)差异均有统计学意义(P＜0.05)。结论 老年T2DM合并甲状腺功能减退者,糖脂代谢较甲功正常者有差异,且与DKD的发生有关。

关键词: 老年人, 2型糖尿病, 亚临床甲状腺功能减退, 血脂, 尿蛋白

Abstract: Objective To explore the correlation between hypothyroidism and diabetic nephropathy (DKD) in the elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 366 elderly T2DM patients who were diagnosed and treated in the Department of Endocrinology of Jiangsu Provincial Hospital of Traditional Chinese Medicine from January 2019 to December 2020 were selected and divided into normal thyroid function group (normal group) and subclinical hypothyroidism group (hypofunction group). The clinical data were compared between the two groups. Results The proportion of female patients in the hypofunction group was higher than that in the normal group (P<0.05). The incidence rate of DKD in the normal group was significantly lower than that in the hypofunction group (P<0.05). The levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), glycosylated hemoglobin (HbA1c) and urinary albumin creatinine ratio (UACR) showed significant differences between the two groups (P<0.05). Conclusions The glucose and lipid metabolism of the elderly patients with T2DM combined with hypothyroidism is different from that of the patients with normal thyroid function.

Key words: aged, type 2 diabetes mellitus, subclinical hypothyroidism, blood lipid, urinary protein

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