实用老年医学 ›› 2021, Vol. 35 ›› Issue (12): 1265-1268.doi: 10.3969/j.issn.1003-9198.2021.12.014

• 临床研究 • 上一篇    下一篇

口服营养补充在老年认知衰弱病人中的应用研究

俞沛文, 包海童, 陈星, 谈萍, 陈姝, 毛艳, 佟蔷薇   

  1. 210029 江苏省南京市,江苏省人民医院(南京医科大学第一附属医院)老年内分泌科
  • 收稿日期:2021-03-11 出版日期:2021-12-20 发布日期:2021-12-28
  • 通讯作者: 佟蔷薇,Email:qiangwei_tong@163.com
  • 基金资助:
    江苏省卫生健康委员会科研课题(BJ17015)

Oral nutrition supplementation in the elderly patients with cognitive frailty

YU Pei-wen, BAO Hai-tong, CHEN Xing, TAN Ping, CHEN Shu, MAO Yan, TONG Qiang-wei   

  1. Department of Geriatric Endocrine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2021-03-11 Online:2021-12-20 Published:2021-12-28

摘要: 目的 探讨口服营养补充(ONS)疗法在老年认知衰弱(CF)病人中的应用效果。 方法 将80例老年CF病人按随机数表法分为干预组与对照组,每组各40例。对照组给予常规膳食,干预组在对照组基础上给予ONS。干预前及干预6个月后,检测2组血清营养指标[转铁蛋白(TRF)、白蛋白(ALB)、前白蛋白(PAB)、Hb],并进行微型营养评估量表(MNA)、MMSE、Fried生理衰弱表型评估量表(PFP)、基于老年综合评估量表(FI-CGA)评估,测定步行速度与肱三头肌处皮褶厚度(TSF)。 结果 干预后6个月,干预组血清TRF、ALB、PAB及Hb水平,MNA、MMSE评分,TSF均较干预前显著升高,PFP及FI-CGA评分较干预前降低(P<0.05或P<0.01),而对照组上述指标变化不显著(P>0.05)。干预后6个月,2组上述指标比较,差异均有统计学意义(P<0.05)。 结论 ONS疗法可改善老年CF病人的营养状态与认知功能,减轻衰弱及疲劳状态,增强身体机能,建议老年CF病人适当实施ONS。

关键词: 认知衰弱, 口服营养补充, 认知功能, 营养状态, 身体机能, 老年人

Abstract: Objective To explore the effect of oral nutritional supplement (ONS) therapy in the elderly patients with cognitive frailty (CF). Methods Eighty elderly patients with CF were randomly divided into intervention group and control group, with 40 cases in each group. The control group was given regular diet, the intervention group was given ONS on the basis of control group. Before the intervention and 6 months after the intervention, the serum levels of nutritional indicators including transferrin (TRF), albumin (ALB), prealbumin (PAB), hemoglobin (Hb) were detected, the Mini Nutritional Assessment Scale (MNA), Mini-Mental State Examination (MMSE), Fried Frailty Phenotype (PFP), Frailty Index based on comprehensive geriatric assessment (FI-CGA) scores were evaluated, the walking speed and triceps skin fold thickness (TSF) were measured. Results After 6 months of the intervention, the serum levels of TRF, ALB, PAB, Hb, MNA score, MMSE score and TSF of the intervention group were significantly increased, PFP and FI-CGA scores were significantly decreased than those before intervention(P<0.05 or P<0.01 ), while in the control group, there were no significant differences of the above indexes(P>0.05). After 6 months of the intervention, the above indexes of the intervention group were significant improved than those in the control group (P<0.05). Conclusions ONS therapy can improve the nutritional status and cognitive function of the elderly patients with CF, reduce weakness and fatigue, and enhance physical functions. It is recommended that elderly patients with CF implement ONS appropriately.

Key words: cognitive frailty, oral nutritional supplementation, cognitive function, nutritional status, physical function, aged

中图分类号: