实用老年医学

实用老年医学 ›› 2021, Vol. 35 ›› Issue (12): 1262-1264.doi: 10.3969/j.issn.1003-9198.2021.12.013

• 临床研究 • 上一篇    下一篇

循环滤泡辅助T细胞在老年T细胞淋巴瘤感染病人中的价值

郑菲菲, 朱岚, 申卫红   

  1. 214041 江苏省无锡市,江南大学附属医院检验科
  • 收稿日期:2021-03-07 出版日期:2021-12-20 发布日期:2021-12-28
  • 通讯作者: 申卫红,Email:loveswh@163.com
  • 基金资助:
    无锡市卫计委科研面上项目(MS201813)

Value of circulating follicular helper T cells in elderly patients with T-cell lymphoma infection

ZHENG Fei-fei, ZHU Lan, SHEN Wei-hong   

  1. Department of Laboratory Medicine,Affiliated Hospital of Jiangnan University, Wuxi 214041, China
  • Received:2021-03-07 Online:2021-12-20 Published:2021-12-28

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摘要： 目的 探讨循环滤泡辅助T细胞(circulating follicular helper T Cells, cTfh)在老年T细胞淋巴瘤病人中的变化特点。 方法 本研究共纳入T细胞淋巴瘤感染病人、健康对照者以及采用药物治疗的T细胞淋巴瘤病人各55例。采用流式细胞仪检测cTfh细胞表面相关分子标志物CD134,采用ELISA法检测细胞表面相关分子标志物分泌的IL-4、IL-21等相关细胞因子,比较3组结果差异。 结果 T细胞淋巴瘤感染组外周血CD134比例为(22.30±6.45)%,高于健康对照组[(3.70±2.18)%]以及药物治疗组[(12.90±4.68)%],差异均有统计学意义(P<0.05)。 T细胞淋巴瘤感染组血清中IL-21、IL-4的水平明显高于健康对照组及药物治疗组,且药物治疗组明显高于健康对照组,差异均有统计学意义(P<0.05)。 结论 外周血cTfh及其分泌的相关细胞因子可能参与了老年T细胞淋巴瘤病人免疫应答发病机制,并在其中起重要作用。

关键词: 循环滤泡辅助T细胞, T细胞淋巴瘤, 白细胞介素-21, 白细胞介素-4

Abstract: Objective To investigate the changes of circulating follicular helper T (cTfh) cells in the elderly patients with T-cell lymphoma. Methods A total of 55 patients with T-cell lymphoma, 55 healthy controls and 55 patients treated with drugs were recruited in the study. The molecular markers (CD134) related to the surface of cTfh cells in each group were detected by the latest flow cytometry. The expression of interleukin (IL)-4, IL-21 secreted by the molecular markers related to the surface of cTfh cells in each group was detected and compared. Results The results of flow cytometry analysis showed that the proportion of CD134 in peripheral blood of the patients with T-cell lymphoma was higher than that of health control group and drug treatment group (P<0.05). The levels of serum IL-21 and IL-4 in the drug treatment group were significantly lower than those in the T-cell lymphoma group, but still higher than those in the healthy control group (P<0.05). Conclusions CTfh cells and cytokines may play an important role in the pathogenesis of immune response in the elderly patients with T-cell lymphoma.

Key words: circulating follicular helper T, T-cell lymphoma, interleukin-21, interleukin-4

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