高龄亚临床甲状腺功能减退伴T2DM病人血清铁蛋白、CRP与CIMT的相关性研究

doi:10.3969/j.issn.1003-9198.2021.11.013

摘要/Abstract

摘要： 目的研究高龄亚临床甲状腺功能减退(SCH)伴T2DM病人血清铁蛋白(SF)、CRP与颈动脉内膜中层厚度(CIMT)的关系,并探讨CIMT增厚的影响因素。方法选取2018年1月至2020年1月收治的高龄SCH伴T2DM病人78例为共病组,另选取年龄、性别相匹配的单纯SCH(SCH组)及T2DM(T2DM组)病人作为对照。检测受试者SF与CRP水平,使用颈动脉超声检测CIMT。比较3组SF、CRP水平与CIMT;采用Pearson相关分析分析高龄SCH伴T2DM病人SF、CRP水平与CIMT的相关性;采用单因素和多因素Logistic回归分析导致高龄SCH伴T2DM病人CIMT增厚的危险因素。结果共病组的SF、CRP水平与CIMT均高于SCH组、T2DM组(P＜0.001),SCH组与T2DM组SF、CRP水平和CIMT比较,差异无统计学意义(P＞0.05)。Pearson相关分析显示,共病组SF、CRP水平与CIMT呈正相关(P＜0.05)。单因素分析显示,高龄SCH伴T2DM病人CIMT增厚组的SF、CRP、LDL-C、TC、TSH水平、高血压史比例高于正常组,HDL-C水平低于正常组,差异有统计学意义(P＜0.05)。Logistic回归分析显示,SF、CRP、LDL-C、TC是高龄SCH伴T2DM病人CIMT增厚的危险因素,HDL-C是保护因素(P＜0.05)。结论高龄SCH伴T2DM病人SF、CRP水平升高,CIMT增高,且SF、CRP水平与CIMT厚度呈正相关。SF、CRP均是导致病人CIMT增厚的危险因素。

关键词: 亚临床甲状腺功能减退, 2型糖尿病, 颈动脉内膜中层厚度, 动脉粥样硬化

Abstract: Objective To study the relationship between serum ferritin(SF), C-reactive protein (CRP) and carotid intima-media thickness (CIMT) in the elderly patients with subclinical hypothyroidism (SCH) combined with type 2 diabetes mellitus (T2DM), and to analyze the influencing factors of CIMT thickening. Methods From January 2018 to January 2020, seventy-eight elderly patients with SCH complicated with T2DM were selected as the disease group, and the patients with only SCH (SCH group) or T2DM (T2DM group) matched by age and gender were selected as controls. The levels of SF and CRP of all the subjects were detected, and CIMT was detected by carotid ultrasound. The levels of SF, CRP and CIMT were compared between the three groups. Pearson correlation analysis was used to analyze the correlation between SF, CRP and CIMT. Univariate and multivariate Logistic regression analysis was used to evaluate the risk factors of CIMT thickening in the elderly patients with SCH combined with T2DM. Results The levels of SF, CRP and CIMT of the disease group were higher than those of SCH group and T2DM group(P<0.001).There were no statistically significant differences between SCH group and T2DM group in the levels of SF, CRP and CIMT(P＞0.05). Pearson correlation analysis showed that the levels of SF and CRP in the disease group were positively correlated with CIMT (P<0.05). Univariate analysis showed that the levels of SF, CRP, low density lipoprotein (LDL-C), total cholesterol (TC), thyroid stimulating hormone (TSH) and hypertension history in the CIMT thickening group were higher than those in the normal group, while the level of HDL-C in the thickening group was lower than that in the normal group (P<0.05). Logistic regression analysis showed that SF, CRP, LDL-C and TC were risk factors for CIMT thickening in the elderly patients with SCH combined with T2DM, and HDL-C was a protective factor (P<0.05). Conclusions The levels of SF, CRP and CIMT are increased in the elderly patients with SCH combined with T2DM, and SF and CRP are the influencing factors of CIMT thickening in the elderly patients with SCH and T2DM.

Key words: subclinical hypothyroidism, type 2 diabetes mellitus, carotid intima-media thickness, atherosclerosis

中图分类号:

林红霞, 刘小平, 翁秀珍. 高龄亚临床甲状腺功能减退伴T2DM病人血清铁蛋白、CRP与CIMT的相关性研究[J]. 实用老年医学, 2021, 35(11): 1157-1161.

LIN Hong-xia, LIU Xiao-ping, WENG Xiu-zhen. Relationship between serum ferritin, CRP and CIMT in elderly patients with subclinical hypothyroidism complicated with T2DM[J]. Practical Geriatrics, 2021, 35(11): 1157-1161.

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