实用老年医学

实用老年医学 ›› 2021, Vol. 35 ›› Issue (11): 1136-1139.doi: 10.3969/j.issn.1003-9198.2021.11.008

• 临床研究 • 上一篇    下一篇

老年HIV感染者认知功能、抑郁状态及服药依从性相关研究

冯彩云, 曾慧, 叶永秀, 熊海燕   

  1. 518109 广东省深圳市,深圳市龙华区人民医院护理部(冯彩云,叶永秀,熊海燕);
    410000 湖南省长沙市,中南大学湘雅护理学院(曾慧)
  • 收稿日期:2020-12-22 发布日期:2021-11-23
  • 通讯作者: 熊海燕,Email: 2451182551@qq.com
  • 基金资助:
    湘雅-加州大学洛杉矶分校HIV/AIDS护理研究计划 (1D43TW009579)

Investigation on cognitive function, depression and drug compliance in elderly patients with HIV

FENG Cai-yun, YE Yong-xiu, XIONG Hai-yan, ZENG Hui   

  1. FENG Cai-yun, YE Yong-xiu, XIONG Hai-yan.Nursing Department, the People's Hospital ofLonghua, Shenzhen 518109,China;
    ZENG Hui. Xiangya College of Nursing, Central South Universily, Changsha 410000, China
  • Received:2020-12-22 Published:2021-11-23

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摘要： 目的 调查湖南省老年HIV感染者的认知功能、抑郁状态及服药依从性并进行相关分析。 方法 采用随机抽样法抽取≥60岁的HIV感染者252例,采用一般信息调查表、MoCA、五项老年抑郁量表(GDS-5)和Morisky服药依从性量表(MMAS-8)收集数据,分析认知功能、抑郁状态及服药依从性的关系。 结果 本研究对象MoCA、GDS-5和MMAS-8得分分别为(18.16±5.57)分、(0.51±1.15)分和(7.56±0.82)分;认知异常的比例为89.2%,有抑郁症状的比例为12.7%,服药高依从率为81.97%、中依从率为16.26%、低依从率为2.77%。认知功能下降幅度最大的认知域为回忆、视空间与执行能力。抑郁症状与服药依从性得分呈负相关(r=-0.243,P<0.01),MoCA得分与抑郁得分呈正相关(r=0.155,P<0.05),但认知功能与服药依从性无相关关系(r＝0.055、P＞0.05)。 结论 老年HIV感染者的认知功能水平较低,抑郁症状较轻微,服药依从性未达到95%目标;老年HIV感染者抑郁情绪与认知功能呈正相关,与服药依从性呈负相关。

关键词: 老年人, 人类免疫缺陷病毒, 认知功能, 相关性分析

Abstract: Objective To investigate the epidemiological status of cognitive function, depression and medication compliance of the elderly patients with human immunodeficiency virus (HIV) in Hunan Province and to conduct correlation analysis. Methods A total of 252 people infected with HIV aged ≥60 years old were selected by the random sampling method. The general social information questionnaire, the Montreal Cognitive Assessment Scale (MoCA), the Five Geriatric Depression Scale (GDS-5), and the Morisky Medication compliance (MMAS-8) were used to investigate the patients' cognitive function, depression and medication adherence status, respectively. Results The scores of MoCA, GDS-5 and MMAS-8 were 18.16±5.57,0.51±1.15 and 7.56±0.82,respectively. The proportion of cognitive abnormalities was 89.2%; The proportion of depressive symptoms was 12.7%; The high compliance rate of taking medicine was 81.97%, the middle compliance rate was 16.26%, and the low compliance rate was 2.77%. The dimensions with greatest decline in cognitive function were memory, visual space and executive ability. Depression was negatively correlated with medication compliance score (r=-0.243, P<0.01), and MoCA score was positively correlated with depression score (r=0.155, P<0.05), but the correlation between cognitive function and medication compliance was not statistically significant (r=0.055, P>0.05). Conclusions The cognitive function is relatively low in the patients infected with HIV, but the depressive symptoms are mild, and medication compliance does not meet 95% as the target. The depression is positively related to cognitive function and negatively related to medication compliance.

Key words: aged, human immunodeficiency virus, cognitive function, correlation analysis

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