Th17/Treg失衡在冠心病中的研究进展

doi:10.3969/j.issn.1003-9198.2021.07.025

摘要/Abstract

中图分类号:

R 541.4

陈西, 刘正霞, 周萍, 刘莹, 鲁翔. Th17/Treg失衡在冠心病中的研究进展[J]. 实用老年医学, 2021, 35(7): 754-757.

[1] GARRIDO-URBANI S, MEGUENANI M, MONTECUCCO F, et al. Immunological aspects of atherosclerosis[J]. Semin Immunopathol, 2014, 36(1):73-91.
[2] HARRINGTON L E, HATTON R D, MANGAN P R, et al. Interleukin 17-producing CD4⁺ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J]. Nat Immunol, 2005, 6(11):1123-1132.
[3] UENO A, JEFFERY L, KOBAYASHI T, et al. Th17 plasticity and its relevance to inflammatory bowel disease[J]. J Autoimmun, 2018, 87:38-49.
[4] MADDUR M S, MIOSSEC P, KAVERI S V, et al. Th17 cells:biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies[J]. Am J Pathol, 2012, 181(1):8-18.
[5] SAKAGUCHI S, SAKGUCHI N, ASANO M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains(CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases[J]. J Immunol, 1995, 155(3):1151-1164.
[6] TAO J H, CHENG M, TANG J P, et al. Foxp3, regulatory T cell, and autoimmunediseases[J]. Inflammation, 2017, 40(1):328-339.
[7] YAN J B, LUO M M, CHEN Z Y, et al. The function and role of the Th17/Treg cell balance in inflammatory bowel disease[J]. J Immunol Res, 2020, 2020:8813558.
[8] WHITESIDE T L. The role of regulatory T cells in cancerimmunology[J]. Immunotargets Ther, 2015, 4:159-171.
[9] TAO L, LIUH, GONG Y. Role and mechanism of the Th17/Treg cell balance in the development and progression of insulin resistance[J]. Mol Cell Biochem, 2019, 459(1/2):183-188.
[10] NOACK M, MIOSSEC P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases[J]. Autoimmun Rev, 2014, 13(6):668-677.
[11] ZHOU L, LOPES J E, CHONG M M W, et al. TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function[J]. Nature, 2008, 453(7192):236-240.
[12] LIU C, YANG H, SHI W, et al. MicroRNA-mediated regulation of T helper type 17/regulatory T-cell balance in autoimmune disease[J]. Immunology, 2018, 155(4):427-434.
[13] LEE G R. The balance of Th17 versus treg cells in autoimmunity[J]. Int J MolSci, 2018, 19(3):730.
[14] CHENG H, GUANX, CHEN D, et al. The Th17/Treg Cell balance:a gut microbiota-modulated story[J]. Microorganisms, 2019, 7(12):583.
[15] O'CONNOR E B, MUNOZ-WOLF N, LEON G, et al. UCP3 reciprocally controls CD4⁺ Th17 and Treg cell differentiation[J]. PLoS One, 2020, 15(11):e0239713.
[16] DING J W, ZHENG X X, ZHOU T, et al. HMGB1 modulates the Treg/Th17 ratio in atherosclerotic patients[J]. J Atheroscler Thromb, 2016, 23(6):737-745.
[17] 杨兵, 林爱琴, 罗晓华, 等. 不同严重程度冠心病患者外周Treg和Th17细胞的测定[J]. 郑州大学学报(医学版), 2018, 53(5):658-661.
[18] LI Q, WANG Y, WANG Y, et al. Treg/Th17 ratio acts as a novel indicator for acute coronary syndrome[J]. Cell Biochem Biophys, 2014, 70(2):1489-1498.
[19] POTEKHINA A V, PYLAEVA E, PROVATOROV S, et al. Treg/Th17 balance in stable cad patients with different stages of coronary atherosclerosis[J]. Atherosclerosis, 2015, 238(1):17-21.
[20] ROSARIO E M M, BOHM M, LINK A. The Th17/Treg imbalance in patients with cardiogenic shock[J]. Clin Res Cardiol, 2014, 103(4):301-313.
[21] 吉庆伟, 吴帮卫, 曾秋棠, 等. HO-1调节Th17/Treg失衡延缓动脉粥样硬化进程的机制研究[J]. 临床心血管病杂志, 2016, 32(2):188-192.
[22] TSILINGIRI K, FUENTE H, RELANO M, et al. Oxidized low-density lipoprotein receptor in lymphocytes prevents atherosclerosis and predicts subclinical disease[J]. Circulation, 2019, 139(2):243-255.
[23] ZHENG Y, WANG Z, DENG L, et al. Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome[J]. Clin Immunol, 2015, 157(1):65-77.
[24] LI Q, WANGY, WANGY, et al. Distinct different sensitivity of Treg and Th17 cells to fas-mediated apoptosis signaling in patients with acute coronary syndrome[J]. Int J Clin Exp Pathol, 2013, 6(2):297-307.
[25] ERBEL C, AKHAVANPOOR M, OKUYUCU D, et al. IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis[J]. J Immunol, 2014, 193(9):4344-4355.
[26] MENG X, YANG J, ZHANG K, et al. Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockoutmice[J]. Hypertension, 2014, 64(4):875-882.
[27] MENG X, YANG J, DONG M, et al. Regulatory T cells in cardiovascular diseases[J]. Nat Rev Cardiol, 2016, 13(3):167-179.
[28] HUANG Y, HU H, LIU L, et al. Interleukin-12p35 deficiency reverses the Th1/Th2 imbalance, aggravates the Th17/Treg imbalance, and ameliorates atherosclerosis in ApoE^-/- Mice[J]. Mediators Inflamm, 2019, 2019:3152040.
[29] LI X, SHAO Y, SHA X, et al. IL-35(interleukin-35)suppresses endothelial cell activation by inhibiting mitochondrial reactive oxygen species-mediated site-specific acetylation of H3K14(histone 3 lysine 14)[J]. Arterioscler Thromb Vasc Biol, 2018, 38(3):599-609.
[30] MA X, LIU S, LI T, et al. Intensive statin treatment ameliorate the Th17/Treg functional imbalance in patients with non-st elevation acute coronary syndrome underwent percutaneous coronary intervention[J]. Clin Cardiol, 2020, 43(4):379-385.
[31] FAN Q, LIU Y, RAO J, et al. Anti-atherosclerosis effect of angong niuhuang pillvia regulating Th17/Treg immune balance and inhibiting chronic inflammatory on ApoE^-/- mice model of early and mid-term atherosclerosis[J]. Front Pharmacol, 2020, 10:1584.
[32] QIU R, LONG J, ZHOU L, et al. Yangyin Qingre Huoxue method in traditional chinese medicine ameliorates atherosclerosis in ApoE^-/- mice suffering from high-fat diet and HSP65 Aggression[J]. Evid Based Complement Alternat Med, 2019, 2019:2531979.

Th17/Treg失衡在冠心病中的研究进展

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