实用老年医学

实用老年医学 ›› 2024, Vol. 38 ›› Issue (2): 149-151.doi: 10.3969/j.issn.1003-9198.2024.02.010

• 临床研究 • 上一篇    下一篇

层粘连蛋白与老年急性心肌梗死病人主要不良心血管事件的相关性

章颖, 谢玲, 叶佳琦, 羌文慧, 严晓云, 姜英, 张清   

  1. 226000 江苏省南通市,南通市第一人民医院全科医学科
  • 收稿日期:2023-03-21 出版日期:2024-02-20 发布日期:2024-02-26
  • 通讯作者: 张清,Email:zzhangqing32@sina.cn
  • 基金资助:
    南通市卫生健康委员会科研课题面上课题(MS2022024)

Correlation between laminin and major adverse cardiovascular events in elderly patients with acute myocardial infarction

ZHANG Ying, XIE Ling, YE Jiaqi, QIANG Wenhui, YAN Xiaoyun, JIANG Ying, ZHANG Qing   

  1. Department of General Practice, Nantong First People's Hospital, Nantong 226000, China
  • Received:2023-03-21 Online:2024-02-20 Published:2024-02-26
  • Contact: ZHANG Qing, Email:zzhangqing32@sina.cn

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摘要： 目的 分析层粘连蛋白(laminin,LN)预测老年急性心肌梗死(acute myocardial infarction, AMI)病人住院期间主要不良心血管事件(major adverse cardiovascular events,MACE)的价值。 方法 回顾性分析在我院接受治疗的132例老年AMI病人资料,根据住院期间是否出现MACE分为事件组和非事件组,观察比较2组LN水平,并分析LN对MACE的预测价值。 结果 132例老年AMI病人中,37例(28.03%)发生MACE,事件组LN水平较非事件组高(P＜0.01)。Logistic回归分析显示,高LN水平是老年AMI病人住院期间发生MACE的独立危险因素(OR=1.010,95%CI:1.001～1.020)。ROC曲线显示,LN预测老年AMI病人发生MACE的AUC为0.819。 结论 LN升高与老年AMI病人院内发生MACE有关。   

关键词: 层粘连蛋白, 急性心肌梗死, 主要不良心血管事件

Abstract: Objective To evaluate the prognostic value of laminin(LN) in predicting major adverse cardiovascular events(MACE) in the elderly patients with acute myocardial infarction(AMI). Methods The data of 132 elderly patients with AMI treated in our hospital were retrospectively analyzed. According to the occurrence of MACE during hospitalization, the patients were divided into the event group and the non-event group. The level of LN was detected and compared between the two groups, and the predictive value of LN on the occurrence of MACE in the elderly patients with AMI was analyzed. Results A total of 37(28.03%) cases presented with MACE in the 132 elderly patients with AMI. The level of LN in the event group was higher than that in the non-event group(P<0.01). Logistic regression analysis showed that high LN level was a risk factor for MACE in the elderly patients with AMI(OR=1.010,95%CI:1.001-1.020). Receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) of LN predicting MACE in the elderly patients with AMI was 0.819. Conclusions The level of LN is associated with the occurrence of MACE in the elderly patients with AMI.

Key words: laminin, acute myocardial infarction, major adverse cardiovascular events

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