实用老年医学

实用老年医学 ›› 2021, Vol. 35 ›› Issue (6): 572-574.doi: 10.3969/j.issn.1003-9198.2021.06.009

• 临床研究 • 上一篇    下一篇

南京地区老年冠状动脉疾病病人ApoE基因多态性与SYNTAX评分的相关性研究

杨杨, 周滢, 田芸凡, 史倞   

  1. 210029 江苏省南京市,南京医科大学第一附属医院(江苏省人民医院)心血管内科
  • 收稿日期:2020-06-29 发布日期:2021-06-29
  • 通讯作者: 史倞,Email:shijing5499@jsph.org.cn
  • 基金资助:
    国家自然科学基金青年科学基金资助项目(81800313)

Relationship between Apolipoprotein E genotype with SYNTAX score in elderly patients with coronary artery disease in Nanjing: a retrospective study

YANG Yang, ZHOU Ying, TIAN Yun-fan, SHI Jing   

  1. Department of Cardiovascular Medicine, the First Affilicated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2020-06-29 Published:2021-06-29

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摘要： 目的 本研究旨在探讨南京地区老年冠状动脉疾病(CAD)病人ApoE基因多态性与SYNTAX评分的相关性。方法 纳入109例经冠状动脉造影(CAG)诊断为CAD的病例,通过SYNTAX评分来评估CAD的复杂程度,采用PCR检测病人ApoE的基因表现型。结果 按ApoE的基因表现型将病人分为3组,其中基因表现型为ApoE2、ApoE3、ApoE4的病人分别有22、71、16例。基因表现型为ApoE2、ApoE3、ApoE4的病人SYNTAX评分的均值分别为(7.75±7.62)分、(14.77±9.52)分和(15.53±7.14)分,组间比较提示ApoE3组及ApoE4组SYNTAX评分显著高于ApoE2组(P＜0.05),而ApoE3组与ApoE4组相比,SYNTAX评分差异无统计学意义。结论 南京地区老年人群基因表现型为ApoE3、ApoE4的病人SYNTAX评分高于ApoE2病人,提示基因表现型ApoE3、ApoE4可能与CAD的复杂程度相关。

关键词: 冠状动脉疾病, 载脂蛋白E, SYNTAX评分, 老年人

Abstract: Objective To investigate the relationship between the polymorphism of Apolipoprotein E (APOE) gene and SYNTAX score in the elderly patients with coronary artery disease (CAD) in Nanjing. Methods A total of 109 patients diagnosed as CAD by coronary angiography (CAG) were enrolled. The complexity of CAD of all the patients was assessed by SYNTAX score, and the genotype of ApoE was detected by polymerase chain reaction. Results The patients were divided into three groups according to the gene phenotype of ApoE. Among them, 22, 71 and 16 patients were identified with the genotype of ApoE2, ApoE3 and ApoE4. The mean value of SYNTAX score of the patients with ApoE2, ApoE3 and ApoE4 was 7.75±7.62, 14.77±9.52 and 15.53±7.14, respectively. The SYNTAX score of ApoE3 group and ApoE4 group was both significantly higher than that of ApoE2 group (P<0.05), while there was no significant difference in SYNTAX score between ApoE3 group and ApoE4 group. Conclusions The elderly patients with the genotype of ApoE3 or ApoE4 have higher SYNTAX score than those with the genotype of ApoE2, suggesting that ApoE3 and ApoE4 may be related with the complexity of CAD.

Key words: coronary artery disease, apolipoprotein E, SYNTAX score, aged

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