潜在转化生长因子结合蛋白2在老年宫颈癌病人血清中的表达及临床意义

doi:10.3969/j.issn.1003-9198.2021.05.013

摘要/Abstract

摘要： 目的探讨潜在转化生长因子结合蛋白2(LTBP2)在老年宫颈癌病人血清中的表达水平及临床意义。方法本研究纳入2017年7月至2019年7月达州市中西医结合医院收治的78例老年宫颈癌病人(宫颈癌组),另纳入同期在我院确诊为慢性宫颈炎的31例病人(宫颈炎组)及在我院体检的37例健康志愿者(对照组),收集宫颈癌病人的临床病理资料,并采用酶联免疫吸附法检测3组血清LTBP2水平。比较3组血清LTBP2水平的差异以及宫颈癌病人手术前后LTBP2水平变化,探讨LTBP2与宫颈癌病人病理特征间的关系。结果宫颈癌组血清LTBP2水平显著高于慢性宫颈炎组和正常对照组(P <0.05),慢性宫颈炎组和正常对照组血清LTBP2水平比较,差异无统计学意义(P >0.05)。不同临床分期、分化程度、有无淋巴结转移病人血清LTBP2水平差异有统计学意义(P <0.05)。宫颈癌病人术后1、3、6个月血清LTBP2水平显著低于手术前,且随着时间逐渐降低(P<0.05)。78例病人中,术前血清LTBP2阳性率为46.15%,术后6个月为2.56%,差异有统计学意义(P<0.05)。结论老年宫颈癌病人血清中LTBP2表达增加,并与临床分期、分化程度及淋巴结转移有一定关系,监测血清LTBP2水平对于老年宫颈癌病人手术前后的病情评估具有一定的临床价值。

关键词: 宫颈癌, 潜在转化生长因子结合蛋白2, 临床病理特征, 老年人

Abstract: Objective To investigate the expression and significance of latent transforming growth factor binding protein 2 (LTBP2) in the serum of the elderly patients with cervical cancer. Methods A total of 78 elderly patients with cervical cancer admitted to our hospital from July 2017 to July 2019 were included in this study. In addition, 31 patients with chronic cervicitis and 37 healthy volunteers who underwent physical examination in our hospital during the same period were included as the control group. The clinical and pathological data of the patients with cervical cancer were collected, and the serum level of LTBP2 was detected by enzyme-linked immunosorbent assay. The differences of serum level of LTBP2 among the three groups were compared, and the relationship between LTBP2 levels and clinicopathological characteristics of cervical cancer was analyzed. Results The level of serum LTBP2 in cervical cancer group was significantly higher than that in the chronic cervicitis group and the control group (P<0.05), while showing no significant difference between the chronic cervicitis group and the control group (P>0.05).There were significant differences in serum level of LTBP2 among the patients with different clinical stages, differentiation degree and lymph node metastasis (P<0.05).The serum level of LTBP2 in the patients with cervical cancer 1,3,6 months after operation was significantly lower than that before operation, and gradually decreased with time (P < 0.05).In 78 patients, the positive rate of serum LTBP2 was 46.15% before operation and 2.56% 6 months after operation (P < 0.05). Conclusions The expression of LTBP2 in the serum of the elderly patients with cervical cancer is increased, and it is related to clinical stage, differentiation degree and lymph node metastasis. Monitoring serum level of LTBP2 has certain clinical value for the evaluation of the disease condition of the elderly patients with cervical cancer before and after operation.

Key words: cervical cancer, latent transforming growth factor binding protein 2, clinicopathological features, aged

中图分类号:

R 737.33

唐固平, 李昭会, 陈丽融, 何红梅, 郭进喜. 潜在转化生长因子结合蛋白2在老年宫颈癌病人血清中的表达及临床意义[J]. 实用老年医学, 2021, 35(5): 483-486.

TANG Gu-ping, LI Zhao-hui, CHEN Li-rong, HE Hong-mei, GUO Jin-xi. Expression and clinical significance of latent transforming growth factor binding protein 2 in the serum of elderly patients with cervical cancer[J]. Practical Geriatrics, 2021, 35(5): 483-486.

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