老年消化道肿瘤病人化疗相关性味觉改变及对营养、心理状态和生活质量的影响

doi:10.3969/j.issn.1003-9198.2021.05.005

摘要/Abstract

摘要： 目的探讨老年消化道肿瘤病人化疗相关性味觉改变及对营养、心理状态和生活质量的影响。方法选择2019年1月至2020年1月我院收治的老年消化道肿瘤病人189例,采用中文版化疗相关性味觉改变量表(CiTAS)、营养风险筛查量表2002、焦虑自评量表(SAS)、抑郁自评量表(SDS)及欧洲癌症治疗组织生活质量测定量表(EORTC QLQ-C30)评价病人化疗相关性味觉改变情况、营养状况、心理状态及生活质量情况,并分析其相关性。结果 189例病人中156例出现化疗相关性味觉改变(味觉改变组),占82.54%(156/189)。味觉改变组的各CiTAS评分均高于未改变组(P＜0.05)。味觉改变组存在营养不良风险比例显著高于未改变组(P＜0.05);SAS评分、SDS评分均高于未改变组(P＜0.05);躯体功能、情绪功能、总体健康状况评分均低于未改变组(P＜0.05),恶心呕吐、疲乏、便秘、腹泻、食欲降低、失眠评分均高于未改变组(P＜0.05)。Pearson相关性分析显示,化疗相关性味觉改变病人CiTAS评分与SDS、SAS、生活质量评分均显著相关(P<0.05)。结论老年消化道肿瘤病人化疗相关性味觉改变发生率较高,营养不良风险高,同时对心理状态及生活质量造成严重影响。

关键词: 老年人, 消化道肿瘤, 化疗相关性味觉改变, 营养, 心理状态, 生活质量

Abstract: Objective To explore the chemotherapy-induced taste changes in the elderly patients with gastrointestinal cancer and the effects on nutrition, psychological status and quality of life. Methods A total of 189 elderly patients with gastrointestinal cancer admitted to our hospital from January 2019 to January 2020 were selected. The Chinese version of chemotherapy-induced taste alteration scale(CiTAS), nutrition risk screening scale 2002, self-rating anxiety scale(SAS), self-rating depression scale (SDS) and European cancer treatment organization quality of life scale (EORTC QLQ-C30) were used to evaluate patients’ chemotherapy-induced taste changes, nutritional status, mental status and quality of life, and to analyze their correlation. Results Among 189 patients, 156 cases (82.54%) presented with chemotherapy-induced taste changes, who were assigned to changed group. The CiTAS score of changed group was higher than that of non-changed group(P < 0.05). The incidence rate of malnutrition risk in changed group was higher than that of non-changed group(50.0% vs 21.2%, P<0.05); The SAS score and SDS score of changed group were higher than those of non-changed group(P<0.05); The scores of physical function, emotional function and general health status of changed group were lower than those of non-changed group, and the scores of nausea and vomiting, fatigue, constipation, diarrhea, loss of appetite and insomnia were higher than those of non-changed group (P < 0.05). The CiTAS score was significantly correlated with SAS score, SDS score, and EORTC QLQ-C30 score in changed group. Conclusions The incidence of chemotherapy-induced taste changes in the elderly patients with gastrointestinal cancer is high, and the risk of malnutrition is high, which has a serious impact on the psychological status and quality of life.

Key words: aged, gastrointestinal cancer, chemotherapy-induced taste changes, nutrition, mental state, quality of life

中图分类号:

R 735

倪玉丹, 陈玉红, 徐莉, 梁伟. 老年消化道肿瘤病人化疗相关性味觉改变及对营养、心理状态和生活质量的影响[J]. 实用老年医学, 2021, 35(5): 451-454.

NI Yu-dan, CHEN Yu-hong, XU Li, LIANG Wei. Study on chemotherapy-induced taste changes in elderly patients with gastrointestinal cancer and the effects on nutrition, psychological status and quality of life[J]. Practical Geriatrics, 2021, 35(5): 451-454.

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