老年2型糖尿病病人血清尿酸/肌酐比值与胰岛素抵抗及胰岛B细胞功能的相关性

doi:10.3969/j.issn.1003-9198.2021.04.015

摘要/Abstract

摘要： 目的探讨老年2型糖尿病(T2DM)病人血清尿酸/肌酐比值(SUA/SCr)与胰岛素抵抗及胰岛B细胞功能的相关性。方法选择老年T2DM病人784例(男512例,女272例),均行75 g口服葡萄糖耐量试验(OGTT),并测定SUA、SCr、TG、TC、LDL-C、HDL-C、HbA1c、葡萄糖、胰岛素等指标水平,并计算胰岛素抵抗指数(HOMA-IR)和B细胞功能指标。结果 SUA/SCr水平越高的病人,年龄越小,HbA1c及SCr水平越低,BMI、TG、UA及eGFR水平越高,差异均有统计学意义(均P＜0.01)。SUA/SCr与HOMA-IR(r=0.112,P=0.002)、胰岛分泌功能(HOMA-β)(r=0.189,P<0.001)、InsAUC30(r=0.164,P<0.001)、IG30(r=0.140,P<0.001)、InsAUC120(r=0.193,P<0.001)、IG120(r=0.169,P <0.001)均呈正相关,进一步校正年龄、性别、糖尿病病程、BMI及TG后,上述相关性仍存在(均P＜0.01)。结论老年T2DM病人血清SUA/SCr水平与胰岛素抵抗及胰岛B细胞功能独立正相关。

关键词: 血清尿酸／肌酐比值, 2型糖尿病, 胰岛素抵抗, B细胞功能

Abstract: Objective To explore the association between serum uric acid to creatinine ratio (SUA/SCr ) and insulin resistance or B-cell function in the elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 784 elderly T2DM patients (512 males and 272 females) were enrolled. All patients underwent 75 g oral glucose tolerance test (OGTT). The levels of SUA, SCr, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), hemoglobin A1c (HbA1c), glucose, and insulin were measured. Insulin resistance and B-cell function indexes were calculated. Results The patients with higher level of SUA/SCr were younger, and had lower levels of HbA1c and SCr, while had higher levels of BMI, TG, SUA and eGFR (all P <0. 01). SUA/SCr was positively correlated with HOMA-IR(r=0. 112, P=0. 002), HOMA-β(r =0. 189, P <0. 001), InsAUC30(r=0. 164, P<0. 001), IG30(r=0. 140, P<0. 001), InsAUC120(r=0. 193, P<0. 001) and IG120(r=0. 169, P<0. 001). After further adjustment for age, gender, diabetic duration, BMI and TG, the above correlations remained (all P <0. 01). Conclusions SUA/SCr in the elderly patients with T2DM are positively associated with insulin resistance and B-cell function.

Key words: serum uric acid to creatinine ratio, type 2 diabetes mellitus, insulin resistance, B-cell function

中图分类号:

R 587.1

俞匀, 唐伟, 娄青林. 老年2型糖尿病病人血清尿酸/肌酐比值与胰岛素抵抗及胰岛B细胞功能的相关性[J]. 实用老年医学, 2021, 35(4): 378-381.

YU Yun,TANG Wei, LOU Qing-lin. Association of serum uric acid to creatinine ratio with insulin resistance and B-cell function in elderly patients with type 2 diabetic[J]. Practical Geriatrics, 2021, 35(4): 378-381.

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