实用老年医学

实用老年医学 ›› 2010, Vol. 24 ›› Issue (2): 159-161.

• 论著 • 上一篇    下一篇

尿11-脱氢血栓素B2与老年高教育背景无症状脑梗死患者认知功能的关系

  

  1. 上海交通大学附属第六人民医院老年科
  • 出版日期:2010-04-20 发布日期:2010-03-10

Study on relationship of urinary 11dehydrothromboxane B2 with cognitive function in elderly senior intellectuals with symptomatic cerebral infarction

  • Online:2010-04-20 Published:2010-03-10

摘要：

目的探讨尿11脱氢血栓素B2（11DHTXB2）浓度与高教育背景的老年无症状脑梗死患者认知功能减退之间的关系。方法选取2007年1月至2008年12月我科门诊及住院病人中无症状但经头颅MRI检查明确为脑梗死者60例，所有入选者教育程度均为大学以上（含大学）。取晨尿4 ml，以酶联免疫吸附法测定尿11DHTXB2浓度。由经过统一培训的医师进行简易精神状态量表（MMSE，满分30分）测评及蒙特利尔认知评估（MOCA，满分30分），记录评测结果。使用SPSS 170软件进行统计分析。结果MMSE异常组和MMSE正常组相比，尿11DHTXB2浓度明显升高，MMSE异常组中MMSE评分与尿11DHTXB2浓度呈负相关，MOCA异常组和MOCA正常组相比，尿11DHTXB2浓度明显升高，MOCA异常组中MOCA评分与尿11DHTXB2浓度呈负相关（P均＜001）。结论尿11DHTXB2浓度升高与老年高教育背景无症状脑梗死患者认知功能减退之间存在相关性。

关键词: 11-脱氢血栓素B2, 无症状脑梗死, 教育, 认知功能

Abstract:

ＯｂｊｅｃｔｉｖｅTo discuss the relationships of the level of urinary 11dehydrothromboxane B2 (11DHTXB2) with cognitive function in elderly senior intellectuals with asymptomatic cerebral infarction.ＭｅｔｈｏｄｓSixty patients (40 men, 20 women) with a mean age of 722±61 years, participated in this study and definitely suffered from asymptomatic cerebral infarction confirmed by brain MRI. Their education were all higher than the university levels (including university). Urinary 11DHTXB2 level was detected by enzyme linked immunosorbent assay. MMSE and MOCA were used to assess their cognitives and recorded, then statistical analysis was carried out with SPSS 17.0.ＲｅｓｕｌｔｓThe urinary 11DHTXB2 level of the abnormal MMSE group was apparently higher than that of the normal MMSE group (P＜001). The score of MMSE in the abnormal MMSE group was negatively correlated with the urinary 11DHTXB2 level (P＜001). The urinary 11DHTXB2 level of the abnormal MOCA group was apparently higher than that of the normal MOCA group (P＜001). The score of MOCA in the abnormal MOCA group was negatively correlated with the urinary 11DHTXB2 level (P＜001).ＣｏｎｃｌｕｓｉｏｎｓThe urinary 11DHTXB2 level is correlated with cognitive hypofunction in elderly senior intellectuals with asymptomatic cerebral infarction.

Key words: 11-dehydrothromboxane B2, asymptomatic cerebral infarction, education, cognitive

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