Abstract: Objective To explore the correlation of serum β2 microglobulin (β2-MG) and lipoprotein-related phospholipase A2(Lp-PLA2) with post-stroke cognitive impairment(PSCI) in the patients with acute ischemic stroke (AIS). Methods The AIS patients hospitalized in the Department of Neurology of Shaanxi Provincial People’s Hospital were recruited.Fasting serum levels of β2-MG,Lp-PLA2, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and other indicators were detected at admission.After 3 months of routine treatment,all the patients were divided into PSCI group (MoCA <26) and normal cognition group (MoCA≥26). Multi-variate Logistic regression analysis was performed to analyze the risk factors of PSCI. Finally, Receiver operating characteristic (ROC) curve analysis was carried out to determine the cut-off potint of β2-MG and Lp-PLA2. Results A total of 102 AIS patients were enrolled. The prevalence of PSCI after 3 months of routine treatment was 53.9% (55 cases). The age, the ratio of hypertension,years of education, the serum levels of Lp-PLA2 and β2-MG of the PSCI group were higher than those of the normal cognition group (P<0.05).Logistic regression analysis showed that serum levels of β2-MG, Lp-PLA2 were important risk factors for PSCI (P<0.05). The area under ROC curve of β2-MG,Lp-PLA2 and combined detection was 0.654,0.790, 0.872, with a sensitivity of 80.0%, 78.2%, 87.3%, and a specificity of 66.0%,74.5%, 80.8% respectively. Conclusions AIS patients with higher serum levels of β2-MG, Lp-PLA2 are more likely to occur PSCI 3 months after stroke. These index can be used as the predictors of PSCI.

Key words: cognitive impairment, β2 microglobulin, lipoprotein-related phospholipase A2, acute ischemic stroke